Nowadays, due to a growing number of tissue injuries, in particular, skin wounds, induction and promotion of tissue healing responses can be considered as a crucial step towards a complete regeneration. Recently, biomaterial design has been oriented towards promoting a powerful, effective, and successful healing. Biomaterials with wound management abilities have been developed for different applications such as providing a native microenvironment and supportive matrices that induce the growth of tissue, creating physical obstacles against microbial contamination, and to be used as delivery systems for therapeutic reagents. Until now, numerous strategies aiming to accelerate the wound healing process have been utilized and studied with their own pros and cons. In this review, tissue remodeling phenomena, wound healing mechanisms, and their related factors will be discussed. In addition, different methods for induction and acceleration of healing via cell therapy, bioactive therapeutic delivery, and/or biomaterial-based approaches will be reviewed.
#1Zulfiqar Ali Khan(GCUF: Government College University, Faisalabad)H-Index: 12
#2Shahrin Jamil(GCUF: Government College University, Faisalabad)H-Index: 1
Last. Muhammad Yar(CUI: COMSATS Institute of Information Technology)H-Index: 23
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AbstractVarious kinds of materials are used for wound healing. But natural polymers are more effective in wound healing as compare to synthetic polymers. Chitosan being a natural biopolymer exhibit...
#1Dimple Chouhan(IITG: Indian Institute of Technology Guwahati)H-Index: 12
#2Namit Dey(IITG: Indian Institute of Technology Guwahati)H-Index: 1
Last. Biman B. Mandal(IITG: Indian Institute of Technology Guwahati)H-Index: 38
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Abstract Current advances in skin tissue engineering and wound healing augur well for the development of split or full thickness skin substitutes to recapitulating the native functional skin. These engineered skin substitutes have fared successfully in recent years with exploration of various emerging technologies. As a result, recent clinical practice has been highly evolved incorporating various engineered skin substitutes as an adjunct to accelerate healing and improvement of quality of life ...
Application of “bioactive materials”, as a modified version of biomaterials, can optimize the response of the biological system due to their surface reactivity and formation of strong interactions with the adjacent tissue upon implantation. However, choosing an appropriate bioactive material that suits to the application and provides the desired mechanical, physical, chemical and biological functionality, as well as understanding the aspects of biological reaction to the biomaterial, in particul...
: Free radicals and inflammation in the skin suffering from trauma cause oxidative damage and delayed healing, leading to adverse wound conditions. To adequately investigate the effects of free radicals and controlled immunogenicity for wound healing, we propose a tofu-based hybrid hydrogel with antioxidant and low immunogenicity properties that can be used for wound healing. Tofu, a food source material, was introduced for the first time into gelatin methacryloyl (GelMA) hydrogels by the photo-...
: Red jujube has a long history of consumption for its excellent antioxidant activity and immunoregulation. In this study, red jujube-incorporated gelatin-methacryloyl (GelMA) hydrogels were developed using a programmed mixing method for wound healing. A series of evaluations, including structural characterization, antioxidant activity in vitro and in vivo, immunoregulation, and wound healing effects, were conducted. The results indicated that the introduction of red jujube equipped the GelMA hy...
Immunoisolation of pancreatic islets is a technology in which islets are encapsulated in semipermeable but immunoprotective polymeric membranes. The technology allows for successful transplantation of insulin-producing cells in the absence of immunosuppression. Different approaches of immunoisolation are currently under development. These approaches involve intravascular devices that are connected to the bloodstream and extravascular devices that can be distinguished in micro- and macrocapsules ...
Abstract Cutaneous wound healing in adult mammals is a complex multi-step process involving overlapping stages of blood clot formation, inflammation, re-epithelialization, granulation tissue formation, neovascularization, and remodelling. Re-epithelialization describes the resurfacing of a wound with new epithelium. The cellular and molecular processes involved in the initiation, maintenance, and completion of epithelialization are essential for successful wound closure. A variety of modulators ...
Normal wound healing is a dynamic and complex multiple phase process involving coordinated interactions between growth factors, cytokines, chemokines, and various cells. Any failure in these phases may lead wounds to become chronic and have abnormal scar formation. Chronic wounds affect patients’ quality of life, since they require repetitive treatments and incur considerable medical costs. Thus, much effort has been focused on developing novel therapeutic approaches for wound treatment. Stem-ce...
AbstractThe pathogenic bacteria delay wound healing due to their interaction in the wound area. This study is aimed to evaluate the efficiency of topical rosemary essential oil (REO) loaded into the nanostructured lipid carriers (NLCs) on in vitro antibacterial activity and in vivo infected wound healing process in the animal model. REO-NLCs morphology, size and in vitro antibacterial activity were done. Two circular full-thickness wound (each 6 mm) were made on the back of each mouse and each w...
Abstract Chronic wounds are a prevailing cause of decreased quality of life, being microbial burden a factor hindering the normal wound healing process. Aerogels are nanostructured materials with large surface area (>250 m 2 /g) and high porosity (>96%). In this work, vancomycin-loaded chitosan aerogel beads were tested as a potential formulation to treat and prevent infections at the wound site. Processing of chitosan in the form of aerogels endowed this polysaccharide with enhanced water sorpt...
Last. Ana Oliveira(UCP: Catholic University of Portugal)H-Index: 26
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Wounds affect one's quality of life and should be managed on a patient-specific approach, based on the particular healing phase and wound condition. During wound healing, exudate is produced as a natural response towards healing. However, excessive production can be detrimental, representing a challenge for wound management. The design and development of new healing devices and therapeutics with improved performance is a constant demand from the healthcare services. Aerogels can combine high por...
A one-pot and facile method with assistance of high gravity was applied for the synthesis of inorganic two-dimensional MOF-5 embedded MXene nanostructures. The innovative inorganic MXene/MOF-5 nano...
Context Pressure ulcers or injuries, arise from ischemic damage to soft tissues induced by unrelieved pressure over a bony prominence. They are usually difficult to treat with standard medical therapy and often they recur. In the search for better treatment options, promising alternative forms of treatment are today emerging. Within the field of regenerative medicine, ongoing research on advanced therapies seeks to develop medicinal products based on gene therapy, somatic cell therapy, tissue-en...
#1Mahla Behyari(AUT: Amirkabir University of Technology)H-Index: 1
#2Rana Imani(AUT: Amirkabir University of Technology)H-Index: 13
Last. Hamid Keshvari(AUT: Amirkabir University of Technology)H-Index: 9
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Among wound care products, nanofibrous structure incorporating herbal ingredients with the potential of sustained and localized release are currently of great interest. In this study, the nano-niosomal formulation of an effective herbal ingredient, Ethanolic Extract of Propolis (EEP), is introduced in a silk fibroin (SF)-based nanofibrous mat via blend electrospinning and evaluated as a wound dressing. According to the results, the size and encapsulation efficacy of drug-loaded niosomes are 404....
#1Shirin Nour(AUT: Amirkabir University of Technology)H-Index: 5
#2Rana Imani(AUT: Amirkabir University of Technology)H-Index: 13
Last. Ali Sharifi(IUMS: Iran University of Medical Sciences)H-Index: 32
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Skin injuries and in particular, chronic wounds, are one of the major prevalent medical problems, worldwide. Due to the pivotal role of angiogenesis in tissue regeneration, impaired angiogenesis can cause several complications during the wound healing process and skin regeneration. Therefore, induction or promotion of angiogenesis can be considered as a promising approach to accelerate wound healing. This article presents a comprehensive overview of current and emerging angiogenesis induction me...
Last. Jiayu Lu(SJTU: Shanghai Jiao Tong University)H-Index: 4
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Platelet aggregates, such as PRP, PRF, and CGF, have been used alone or in combination with other grafting materials to enhance restoration outcomes. The process for preparing these autografting materials requires two-step centrifugation or specific centrifuges. In this study, we obtained an injectable fibrin scaffold (IFS) rich in growth factors by one-step centrifugation of whole blood from rabbits. The purpose of this study is to introduce some characteristics of IFS. This scaffold was charac...
#1Yu Na Han(Catholic University of Korea)H-Index: 1
#2Yoon Jae Lee(Catholic University of Korea)H-Index: 6
Last. Jong Won Rhie(Catholic University of Korea)H-Index: 21
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BACKGROUND Verapamil is used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, hypertrophic scars, and keloids to block transmembrane calcium ion flux. Verapamil has antioxidant activity, which enhances the production of nitric oxide (NO). NO promotes the proliferation of fibroblasts, keratinocytes, endothelial cells, and epithelial cells during wound healing. In this study, we investigated the effect of verapamil and its antioxidant properties on the enhancement of acute wo...
Synthesis of metal nanoparticles using plant extracts is one of the most simple, convenient, economical, and environmentally friendly methods that mitigate the involvement of toxic chemicals. Hence, in recent years, several eco-friendly processes for the rapid synthesis of silver nanoparticles have been reported using aqueous extracts of plant parts such as the leaf, bark, roots, etc. This review summarizes and elaborates the new findings in this research domain of the green synthesis of silver ...