Pharmacodynamic and Clinical Evaluation of Low-Volume Polyethylene Glycol (PEG)-Based Bowel Cleansing Solutions (NER1006) Using Split Dosing in Healthy and Screening Colonoscopy Subjects

Introduction: The effectiveness of PEG3350+electrolytes-based solutions for bowel cleansing prior to endoscopy is well established, but requires patients to drink ≥3 L of fluid. Reducing this volume without compromising efficacy/safety is the next challenge. Methods: This open-label, randomized, 2-part (Part A: healthy subjects; Part B: screening colonoscopy subjects), phase II study investigated the pharmacodynamics (stool weight),...