In search for the ideal anatomical composition of vascularised human skin equivalents for systemic sclerosis translational research: should we recruit the telocytes?

The recent paper by Matei et al 1 has raised our interest on the feasibility and reliability of vascularised human skin equivalents for fibrosis research. This is a novel in vitro model which may replicate key features of fibrotic skin and may become a valuable platform for preclinical testing of innovative therapeutic strategies for systemic sclerosis (SSc) and other cutaneous fibrosing conditions. In this informative study, an engineered human...