The development of photoactive and biocompatible nanostructures is a highly desirable goal to address the current threat of antibiotic resistance. Here, we describe a novel supramolecular biohybrid nanostructure based on the non-covalent immobilization of cationic zinc phthalocyanine (ZnPc) derivatives onto unmodified cellulose nanocrystals (CNC), following an easy and straightforward protocol, in which binding is driven by electrostatic interactions. These non-covalent biohybrids show strong photodynamic activity against S. aureus and E. coli, representative examples of Gram-positive and Gram-negative bacteria, respectively, and C. albicans, a representative opportunistic fungal pathogen, outperforming the free ZnPc counterparts and related nanosystems in which the photosensitizer is covalently linked to the CNC surface.
The behavior of nanoparticles in solution is largely dominated by their shape and interaction potential. Despite considerable progress in the preparation of patchy and compartmentalized particles, access to nanoparticles with complex surface patterns and topographies remains limited. Here, we show that polyanionic brushes tethered to rod-like cellulose nanocrystals (CNCs) spontaneously develop a striped or helical topography through interpolyelectrolyte complexation with polycationic diblock cop...
This review highlights and summarizes various optically active porphyrin and phthalocyanine molecules prepared using a wide range of structural modification methods to improve the design of novel structures and their applications. The induced chirality of some illustrative achiral bis-porphyrins with a chiral guest molecule is introduced because these systems are ideal for the identification and separation of chiral biologically active substrates. In addition, the relationship between CD signal ...
Last. Vefa Ahsen(GIT: Gebze Institute of Technology)H-Index: 54
view all 5 authors...
Abstract The use of metallo phthalocyanines (MPcs) in technological applications requires certain methodological approaches for thin film fabrication. Among these applications the implementation of MPc films is in electronic devices such as organic field-effect transistors (OFETs) and photovoltaic (PV) devices. For such applications the control of alignment and ordering of MPc molecules within the films remains a considerable challenge. This review provides an overview of films⿿ growth of mesoge...
Encapsulation of oxygen sensitive components is important in several areas, including those in the food and pharmaceutical sectors, in order to improve shelf-life (oxidation resistance). Neat nanoc ...
Last. Tomás Torres(UAM: Autonomous University of Madrid)H-Index: 97
view all 8 authors...
Exploring new properties in known materials, sometimes even achieving behaviors opposite to those traditionally encountered, is a fundamental aspect of innovation in materials science. In the field of energy conversion, for example, the development of water-processed organic solar cells provides environmentally friendlier materials, which contribute to reduce health risks. Herein, a novel approach is described to produce water-soluble electron-donor single wall carbon nanotube (SWCNT) hybrids ba...
#1Michal Kryjewski(Poznan University of Medical Sciences)H-Index: 9
#2Tomasz Goslinski(Poznan University of Medical Sciences)H-Index: 22
Last. Jadwiga Mielcarek(Poznan University of Medical Sciences)H-Index: 21
view all 3 authors...
Abstract The binding of cyclodextrins and porphyrinoids (including porphyrins, phthalocyanines and chlorins) is carried out by both covalent linking or inclusion complexation. Many of the resulting structures possess intrinsic biomimetic functionality. Therefore, they have been investigated as biomimetics, which imitate some biochemical processes occurring in nature, such as carotene cleavage, cytochrome P450-mediated hydroxylation, oxygen binding by hemoglobin, or as components of multichromoph...
We report a facile aqueous procedure to create multivalent displays of sulfonated ligands on CNCs for future applications as viral inhibitors. CNCs were decorated with model compounds containing sulfonate groups via reactions of epoxides and isothiocyanates with amines under alkaline conditions. At first, surface sulfate groups of CNCs were hydrolytically cleaved by alkaline hydrolysis to increase the number of available surface hydroxyls. Success of desulfation was confirmed via dynamic light s...
Last. Michal Heger(UU: Utrecht University)H-Index: 33
view all 9 authors...
Contemporary photodynamic therapy (PDT) for the last-line treatment of refractory cancers such as nasopharyngeal carcinomas, superficial recurrent urothelial carcinomas, and non-resectable extrahepatic cholangiocarcinomas yields poor clinical outcomes and may be associated with adverse events. This is mainly attributable to three factors: (1) the currently employed photosensitizers exhibit suboptimal spectral properties, (2) the route of administration is associated with unfavorable photosensiti...
#1Liqiang Jin(Qilu University of Technology)H-Index: 5
#2Weigong Li(Qilu University of Technology)H-Index: 1
Last. Qiucun Sun(Qilu University of Technology)H-Index: 3
view all 4 authors...
In this present work, amino-functionalized nanocrystalline cellulose (ANCC) was prepared by a process involving, (1) extraction of nanocrystalline cellulose (NCC) from fully bleached hardwood kraft pulp by sulfuric acid hydrolysis, (2) sodium periodate oxidation of NCC to yield the corresponding C-2/C-3 dialdehyde nanocellulose (DANC) and (3) grafting with ethylenediamine to obtain ANCC through a reductive amination treatment. Properties of DANC and ANCC were characterized by conductometric titr...
#2Ning Yan(U of T: University of Toronto)H-Index: 31
Copper-tetrasulfonate phthalocyanine was incorporated on cellulose nanocrystals to act as a high yield, heterogeneous, and selective catalyst for the aerobic oxidation of alcohols and alkyl arenes to the corresponding carbonyl groups in an aqueous green solvent.
Last. Hassan Farhid(Shahid Beheshti University)H-Index: 4
view all 6 authors...
Abstract null null In this investigation, MIL-101-NH2 chemically functionalized with cobalt(II) tetrasulfophthalocyanine (CoTSPc) through a superior electrostatic interaction reaction. The configuration of the synthesized composite was characterized using Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), thermal gravimetric analysis (TGA), energy-dispersive X-ray spectroscopy (EDS), scanning electron microscope (SEM), and inductively coupled plasma optical emission spectro...
In the endeavor of extending the clinical use of photodynamic therapy (PDT) for the treatment of superficial cancers and other neoplastic diseases, deeper knowledge and control on the subcellular processes that determine the response of photosensitizers (PS) are needed. Recent strategies in this direction involve the use of activatable and nanostructured PS. Herein both capacities have been tuned in two dendritic zinc (II) phthalocyanine (ZnPc) derivatives, either asymmetrically or symmetrically...
Last. Gema de la Torre(UAM: Autonomous University of Madrid)H-Index: 33
view all 6 authors...
Herein, the photodynamic activity of phthalocyanine-assembled nanoparticles against bacterial strains is demonstrated. The photosensitizers (PS) studied in this work are two chiral Zn(II)Pcs (PS-1 and PS-2), with an AABB geometry (where A and B refer to differently substituted isoindole constituents) containing differently functionalized, chiral binaphthyloxy-linked A isoindole units, which determine the hydrophobicity of the system, and cationic methyl pyridinium moieties in the other two isoin...
One of the most promising alternatives for treating bacterial infections is antimicrobial photodynamic therapy (aPDT), making the synthesis and application of new photoactive compounds called photosensitizers (PS) a dynamic research field. In this regard, phthalocyanine (Pc) derivatives offer great opportunities due to their extraordinary light-harvesting and tuneable electronic properties, structural versatility, and stability. In this review, rather than focusing on synthetic strategies, I int...
This review focuses on the description of several examples of supramolecular assemblies of phthalocyanine derivatives differently functionalized and interfaced with diverse kinds of chemical species for photo-induced phenomena applications. In fact, the role of different substituents was investigated in order to tune peculiar aggregates formation as well as, with the same aim, the possibility to interface these derivatives with other molecular species, as electron donor and acceptor, carbon allo...
We report highly fluorescent cellulose nanocrystals (CNCs) formed by conjugating a carboxylated zinc phthalocyanine (ZnPc) to two different types of CNCs. The conjugated nanocrystals (henceforth ca...
Antimicrobial resistance is threatening to overshadow last century’s medical advances. Previously eradicated infectious diseases are now resurgent as multi-drug resistant strains, leading to expensive, toxic and, in some cases, ineffective antimicrobial treatments. Given this outlook, researchers are willing to investigate novel antimicrobial treatments that may be able to deal with antimicrobial resistance, namely Photodynamic Therapy (PDT). PDT relies on the generation of toxic reactive oxygen...
New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal-complexes offer access to potential alternative modes of action and have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity against drug resistant bacteria. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.
