Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals

Published on Mar 28, 2017in Chemistry: A European Journal4.857
· DOI :10.1002/CHEM.201605285
Eduardo Anaya-Plaza8
Estimated H-index: 8
(UAM: Autonomous University of Madrid),
Eveline van de Winckel5
Estimated H-index: 5
(UAM: Autonomous University of Madrid)
+ 9 AuthorsAndrés de la Escosura23
Estimated H-index: 23
(UAM: Autonomous University of Madrid)
The development of photoactive and biocompatible nanostructures is a highly desirable goal to address the current threat of antibiotic resistance. Here, we describe a novel supramolecular biohybrid nanostructure based on the non-covalent immobilization of cationic zinc phthalocyanine (ZnPc) derivatives onto unmodified cellulose nanocrystals (CNC), following an easy and straightforward protocol, in which binding is driven by electrostatic interactions. These non-covalent biohybrids show strong photodynamic activity against S. aureus and E. coli, representative examples of Gram-positive and Gram-negative bacteria, respectively, and C. albicans, a representative opportunistic fungal pathogen, outperforming the free ZnPc counterparts and related nanosystems in which the photosensitizer is covalently linked to the CNC surface.
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