Effects of natalizumab therapy on intrathecal antiviral antibody responses in MS

To investigate the effects of natalizumab (NAT) treatment on intrathecally produced antiviral antibodies in MS.We performed a longitudinal, observational study analyzing both serum and CSF samples collected before and during NAT treatment for antibodies against measles, rubella, mumps, influenza, entero, herpes, and polyoma viruses, including JC polyomavirus (JCV) and its nearest homologue BK polyomavirus (BKV), and bacterial control antigens by...