Total gray matter volume is reduced in individuals with bipolar disorder currently treated with atypical antipsychotics

Recent evidence indicates that the intake of atypical antipsychotics (AAP) is associated with gray matter abnormalities in patients with psychiatric disorders. We explored if patients with bipolar disorder (BD) who are medicated with AAP exhibit total gray matter volume (TGV) reduction compared to BD individuals not medicated with AAP and healthy controls (HC). In a cross-sectional design, 124 individuals with BD and 86 HC underwent 3T-MRI of...