T Cell Activation Depends on Extracellular Alanine
Abstract
T cell stimulation is metabolically demanding. To exit quiescence, T cells rely on environmental nutrients, including glucose and the amino acids glutamine, leucine, serine, and arginine. The expression of transporters for these nutrients is tightly regulated and required for T cell activation. In contrast to these amino acids, which are essential or require multi-step biosynthesis, alanine can be made from pyruvate by a single transamination....
Paper Details
Title
T Cell Activation Depends on Extracellular Alanine
Published Date
Sep 1, 2019
Journal
Volume
28
Issue
12
Pages
3011 - 3021.e4
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