Effect of early-stage autophagy inhibition in BRAFV600E autophagy-dependent brain tumor cells

Autophagy is a multistage process. Progress within the field has led to the development of agents targeting both early (initiation) and late (fusion) stages of this process. The specific stage of autophagy targeted may influence cancer treatment outcomes. We have previously shown that central nervous system (CNS) tumors with the BRAF V600E mutation are autophagy dependent, and late-stage autophagy inhibition improves the response to targeted...