Gene

Pharmacokinetics

Cancer

Internal medicine

Refractory (planetary science)

Oncology

Vemurafenib

Dabrafenib

Solid tumor

Metastatic melanoma

Mutation

Genetics

Medicine

Biology

Astrobiology

Clinical Cancer Research

The 2-part, phase I/IIa, open-label study (NCT01677741) sought to determine the safety, tolerability, pharmacokinetics, and preliminary activity of dabrafenib in pediatric patients with advanced

A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory <i>BRAF</i> V600 Mutation–Positive Solid Tumors

A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation–Positive Solid Tumors