Histiocytic Sarcoma Following B-Lymphoblastic Leukemia/Lymphoma

Objectives Rare cases of clonally related histiocytic sarcoma (HS) following B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) have been reported to date. Methods We present a patient with HS, which appeared as a breast mass 12 months after the initial diagnosis of B-ALL. Results Both HS and the B-ALL shared IGH-MYC and IGK gene rearrangements. Next-generation sequencing and whole-exome sequencing (WES) studies detected 35 common mutations, as well...