Internal medicine

Pathology

Virus

Salmonella

Diarrheal diseases

Bacteria

Epithelium

Biology

Microbiology

Infectivity

Pathogen

Immunology

Shigella

Diarrhea

Intestinal mucosa

Intestinal epithelium

Cell biology

Enteric virus

Genetics

Medicine

Cell Host & Microbe

Grassart et al. employ Organ-on-Chip to interrogate the impact of intestinal mechanical forces on Shigella infection. In the 3D microenvironment, Shigella infects enterocytes from the apical side, exploiting the crypt-like invaginations for early colonization, while intestinal peristalsis enhances invasion. Collectively, Organ-on-Chip reveals that Shigella leverages the intestinal microarchitecture and mechanical forces.

Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection