Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates
Abstract
Antibody–drug conjugates (ADCs) that incorporate the exatecan derivative DXd in their payload are showing promising clinical results in solid tumor indications. The payload has an F-ring that also contains a second chiral center, both of which complicate its synthesis and derivatization. Here we report on new camptothecin-ADCs that do not have an F-ring in their payloads yet behave similarly to DXd-bearing conjugates in vitro and in vivo. This...
Paper Details
Title
Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates
Published Date
Sep 6, 2019
Volume
10
Issue
10
Pages
1386 - 1392
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