Internal medicine

Neuroscience

Calcium signaling

Disease

Biology

Calcium in biology

Neuropathology

Sodium-calcium exchanger

Calcium

Mitochondrion

Cell biology

Alzheimer's disease

Medicine

Intracellular

Calcium metabolism

Nature Communications

Impairments in neuronal intracellular calcium ( i Ca 2+ ) handling may contribute to Alzheimer’s disease (AD) development. Metabolic dysfunction and progressive neuronal loss are associated with AD progression, and mitochondrial calcium ( m Ca 2+ ) signaling is a key regulator of both of these processes. Here, we report remodeling of the m Ca 2+ exchange machinery in the prefrontal cortex of individuals with AD. In the 3xTg-AD mouse model impaired m Ca 2+ efflux capacity precedes neuropathology. Neuronal deletion of the mitochondrial Na + /Ca 2+ exchanger (NCLX, Slc8b1 gene) accelerated memory decline and increased amyloidosis and tau pathology. Further, genetic rescue of neuronal NCLX in 3xTg-AD mice is sufficient to impede AD-associated pathology and memory loss. We show that m Ca 2+ overload contributes to AD progression by promoting superoxide generation, metabolic dysfunction and neuronal cell death. These results provide a link between the calcium dysregulation and metabolic dysfunction hypotheses of AD and suggest m Ca 2+ exchange as potential therapeutic target in AD.

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease