Abstract CuO and ZnO nanoparticles (NPs) were synthesized at room-temperature following a novel, direct, high-yield (>91%) and green method based on a mechanically activated metathesis reaction. The CuO-NPs exhibited a rod-like shape with average length and diameter of 22 and 6 nm, respectively, while the ZnO-NPs showed spherical-like morphology and mean diameter of 15 nm, as determined by TEM. The antimicrobial properties of the NPs and commercially available micrometric counterparts were evaluated by the micro dilutions method to determine the minimum inhibitory concentrations against reference strains from ATCC microorganisms, which were representative of the main groups of bacteria related to human infections, such as E. coli, S. aureus, E. faecalis and P. aeruginosa. The CuO and ZnO-NPs showed better antibacterial properties (500 μg/mL) in comparison with the commercial micrometric particles (1000 μg/mL). The analysis of the synergism between both NPs and ampicillin showed a decrease of their concentrations against all the microorganisms studied, with the ZnO-NPs showing better synergism activity than CuO-NPs, whereas the combination of the antibiotic with ZnO-NPs showed a six-fold decrease against all the microorganisms studied except to P. aeruginosa. The FIC index was calculated with both NPs and ampicillin to each bacterium. In most cases, the effect was partial synergism, and an additive effect was achieved when those combinations were evaluated against P. aeruginosa. The cell viability tests showed that the CuO and ZnO-NPs synthesized and mixed with the antibiotic are biocompatible in effective doses (
As current levels of antimicrobial resistance are alarming, the World Health Organization urged the development of new antimicrobials to fight infections produced by multidrug resistant bacteria. Antibiotics impose severe selective pressure for the development of resistance, and currently bacteria resistant to all of them exist. In this review, we discuss the release and development of new antibacterial drugs and their properties as well as the current advances in the development of alternative ...
Chitosan exhibits a wide range of bio-properties, including biocompatibility, antimicrobial activity, and biodegradability. In this study, we prepared bionanocomposites by using chitosan/gelatin with different concentrations of silver-loaded zinc oxide nanoparticles. The silver-loaded ZnO nanoparticles were synthesized using the sol–gel method with a gelatin template. The bionanocomposite films were prepared via green chemistry approach, using a solution casting method. The bionanocomposites wer...
#1Chandradhish Ghosh(Jawaharlal Nehru Centre for Advanced Scientific Research)H-Index: 14
#2Paramita Sarkar(Jawaharlal Nehru Centre for Advanced Scientific Research)H-Index: 10
Last. Jayanta Haldar(Jawaharlal Nehru Centre for Advanced Scientific Research)H-Index: 33
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As more antibiotics are rendered ineffective by drug-resistant bacteria, focus must be shifted towards alternative therapies for treating infections. Although several alternatives already exist in nature, the challenge is to implement them in clinical use. Advancements within biotechnology, genetic engineering, and synthetic chemistry have opened up new avenues towards the search for therapies that can substitute for antibiotics. This review provides an introduction to the various promising appr...
Abstract A facile one step green synthesis of silver (AgNP), gold (AuNP) and platinum (PtNP) nanoparticles has been attempted using the rind extract of the fruit of Garcinia mangostana L. The rind of the fruit is enriched with wide varieties of natural resources which could be conveniently exploited as alternative for synthesis of nanoparticles eliminating the need for hazardous chemical methods. The formation of gold nanoparticles occurred at room temperature within a few seconds while the form...
Abstract Preparation of hitherto unreported chitosan/poly(vinyl alcohol)/ZnO nanocomposites film (designated as CS/PVA/ZnO) as an efficient bio-based nanocomposites is carried out by a greener approach involving mixing, solution casting and solvent evaporation. Synthesized chitosan-based nanocomposites films are characterized by various analytical techniques such as Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron...
Last. Zhenyu Cheng(Dal: Dalhousie University)H-Index: 17
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Abstract Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of P. aeruginosa has become increasingly difficult due to its remarkable capacity to resist antibiotics. Strains of Pseudomonas aeruginosa are known to utilize their high levels of intrinsic and acquired resistance mechanisms to counter most antibiotics. In addition, adaptive antibiotic resistance of P. aerugino...
Abstract In living organisms, biofilms are defined as complex communities of bacteria residing within an exopolysaccharide matrix that adheres to a surface. In the clinic, they are typically the cause of chronic, nosocomial, and medical device-related infections. Due to the antibiotic-resistant nature of biofilms, the use of antibiotics alone is ineffective for treating biofilm-related infections. In this review, we present a brief overview of concepts of bacterial biofilm formation, and current...
The increase in the prevalence of bacterial resistance to antibiotics has become one of the main health problems worldwide, thus threatening the era of antibiotics most frequently used in the treatment of infections. The need to develop new therapeutic strategies against multidrug resistant microorganisms, such as the combination of selected antimicrobials, can be considered as a suitable alternative. The in vitro activities of two groups of conventional antimicrobial agents alone and in combina...
Abstract By following a one-step, novel methodology, ZnO and Ag/ZnO heterostructures were successfully synthesized at room-temperature. This route is simple, effective, high yield (91%), environmentally friendly (green synthesis) and consists of a mechanically assisted metathesis reaction. The metathesis reaction used in this investigation showed two results: the in-situ generation of alkaline nitrates, LiNO3/NaNO3, and the direct crystallization of the desired Zn-based compounds in milling medi...
During the last decade, there have been enormous developments in utilizing the power of nanotechnology in various fields including biomedical sciences. The most important biomedical applications of nanoparticles (NPs) are in disease diagnosis and treatment. Functionalized NPs possess unique properties as contrast agents for dual and even triple modal imaging. The potential of these new generation NPs in targeted drug delivery has revolutionized safe and effective pharmacotherapies for complex di...
Last. Abdolrazagh Marzban(Lorestan University of Medical Sciences)H-Index: 7
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For the first time, an aqueous extract of Melilotus officinalis was used to synthesize bimetallic silver selenide chalcogenide nanostructures (Ag2Se-NCs). The formation of NCs was confirmed and characterized by UV–visible and FTIR spectroscopy, SEM and TEM imaging, XRD and EDX crystallography, zeta potential (ZP) and size distribution (DLS). The bioactivities of biosynthesized Ag2Se-NCs, such as antibacterial, antibiofilm, antioxidant and cytotoxicity potentials, were then examined. Bio-based Ag...
Last. Lia-Mara Dițu(UB: University of Bucharest)H-Index: 1
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In this study, zinc oxide nanoparticles were synthesized through a simple co-precipitation method starting from zinc acetate dihydrate and sodium hydroxide as reactants. The as-obtained ZnO nanoparticles were morphologically and structurally characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), photocatalytic activity, and by determining the antimicrobial activity against Gram-negative...
Biogenic nanocrystals (NCs) were synthesized from Ginkgo biloba leaf extract (GLE) and applied as photocatalytic and antibacterial agents. XRD patterns revealed the formation of ZnO/CuO NCs with a crystalline quality and intra-granular coupling, and HRTEM images showed the globular morphology indicating a porous nature. The lower PL intensity of ZnO/CuO NCs specified the slower recombination rate of electrons and holes for enhanced photocatalytic and antibacterial activity. The maximum photocata...
#2Sunil H. Chaki(SPU: Sardar Patel University)H-Index: 19
Last. M. P. Deshpande(SPU: Sardar Patel University)H-Index: 17
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Abstract A simple wet precipitate technique is used to synthesis CuO nanoparticles. The copper chloride and sodium hydroxide are used as precursor. The powder X-ray diffraction confirmed the CuO phase of the synthesized nanoparticles having monoclinic unit cell structure. The near perfect stoichiometry of the synthesized nanoparticles is confirmed by the analysis of the dispersive X-rays technique. The spherical shape and nanostrips morphology is confirmed by the electron microscopy in the field...
Synthetic synthesis of nanoparticles is harmful to human and environment due to pollution. The use of harmful chemicals in synthetic method has avoided in the biosynthesis. To overcome the hurdles in synthesis of nanoparticles, the biogenic synthesis of CuO nanoparticles has been done with Plectranthus amboinicus leaf extracts. The biosynthesis provides the enhanced efficiency compared to synthetic methods. It establishes the environmentally friendly and pollution-free approach. The powder X-ray...
Abstract The green synthesis of CuO nanoparticles was synthesized by Allium sativum extract. The powder X-ray diffraction pattern explained the high crystalline nature and the calculated crystallite size in 25−35 nm. The Fourier transform infrared spectrum described the CuO bonding nature. The UV visible analysis reported the surface Plasmon resonance band at 398 nm. The Photoluminescence spectrum denoted the red band emission in the visible region. The particle size analyzer displayed the CuO n...
Last. Stefan Jurga(Adam Mickiewicz University in Poznań)H-Index: 33
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Abstract ZnO (nano)structures remain of great interest in biomedical applications due to their unique properties and possible morphologies. Biocompatibility of typically fabricated ZnO structures remains questionable and they still lack desired biological functions, whence their functionalization is of high interest. In this work, we fabricated micro-sized ZnO hierarchical flower-like structures using facile template-free hydrothermal method to act as carriers for the delivery of gold nanopartic...
#2Pooyan Makvandi(IUMS: Iran University of Medical Sciences)H-Index: 20
Last. Vinod V.T. Padil(Technical University of Liberec)H-Index: 17
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Gum polysaccharides are derived from renewable sources. They are readily available, inexpensive, non-hazardous and eco-friendly. Depending upon the source, gums may be categorized as microbial gums, plant exudate gums or seed gums. Naturally occurring gum carbohydrates find multiple applications in the biomedical arena, compared with synthetic compounds, because of their unique structures and functionalities. Gums and their biocomposites are preferred for sustained drug delivery because they are...