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Original paper

Mechanism of Enhanced MerTK-Dependent Macrophage Efferocytosis by Extracellular Vesicles

Volume: 39, Issue: 10, Pages: 2082 - 2096
Published: Aug 22, 2019
Abstract
Extracellular vesicles secreted by cardiosphere-derived cells (CDCev) polarize macrophages toward a distinctive phenotype with enhanced phagocytic capacity (MCDCev). These changes underlie cardioprotection by CDCev and by the parent CDCs, notably attenuating the no-reflow phenomenon following myocardial infarction, but the mechanisms are unclear. Here, we tested the hypothesis that MCDCev are especially effective at scavenging debris from dying...
Paper Details
Title
Mechanism of Enhanced MerTK-Dependent Macrophage Efferocytosis by Extracellular Vesicles
Published Date
Aug 22, 2019
Volume
39
Issue
10
Pages
2082 - 2096
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