Anatomy

Diabetic neuropathy

Sciatic nerve

Endocrinology

Hyperalgesia

Internal medicine

Axon

Peripheral neuropathy

Medicine

Nociception

Receptor

Hypoalgesia

Degeneration (medical)

Pathology

Streptozotocin

Diabetes mellitus

Diabetes

Diabetic peripheral neuropathy (DPN) is the most common complication in both type 1 and type 2 diabetes, but any treatment toward the development of DPN is not yet available. Axon degeneration is an early feature of many peripheral neuropathies, including DPN. Delay of axon degeneration has beneficial effects on various neurodegenerative diseases, but its effect on DPN is yet to be elucidated. Deficiency of Sarm1 significantly attenuates axon degeneration in several models, but the effect of Sarm1 deficiency on DPN is still unclear. In this study, we show that Sarm1 knockout mice exhibit normal glucose metabolism and pain sensitivity, and deletion of the Sarm1 gene alleviates hypoalgesia in streptozotocin-induced diabetic mice. Moreover, Sarm1 gene deficiency attenuates intraepidermal nerve fiber loss in footpad skin; alleviates axon degeneration, the change of g-ratio in sciatic nerves, and NAD+ decrease; and relieves axonal outgrowth retardation of dorsal root ganglia from diabetic mice. In addition, Sarm1 ...

<i>Sarm1</i> Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice

Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice