Abstract The construction of ceramic components with UV curing is a developing trend by an additive manufacturing (AM) technology, due to the excellent advantages of high precision selective fixation and rapid prototyping, the application of this technology to bone defect repair had become one of the hotspots of research. Hydroxyapatite (HAP) is one of the most popular calcium phosphate biomaterials, which is very close to the main ingredient of human bones. Thus, hydroxyapatite biomaterials are popular as bone graft materials. In summary, the preparation of HAP bioceramics by a 3D printing of digital light processing (DLP) is a promising work. However, the preparation of HAP hybrid suspensions with high solid loading and good fluidity that can be printed by DLP encountered some challenges. Therefore, the purpose of this work is to improve and develop a novel UV-curing suspension with a high solids loading, which the suspension with the hydrodynamic properties and stability are suitable for DLP printer, in order to compensate for the brittleness of HAP ceramics itself to a certain extent, a low amount of zirconia was added in the suspension as an additive to fabricate a zirconia toughened HAP bioceramic composite by a DLP of 3D printing. In this work, the HAP powder was pre-modified by two organic modifiers to improve the compatibility in the acrylic resin system, and the addition of the castor oil phosphate further reduced the shear stress of the suspension to ensure strong liquidity. The UV suspension with 60 wt% powder particle loading had a minimum viscosity of 7495 mPa·s at 30 rpm, which was vacuum sintered at 1100 °C, 1200 °C, and 1250 °C, respectively. The composite ceramics (with 6 wt% ZrO2) at 1200 °C had a relative density of 90.7%, while the sintered samples at 1250 °C had stronger tensile strength and bending strength. The toughening effect of zirconia incorporation on HAP ceramics was also confirmed by the change of tensile modulus and bending modulus, whereas the corresponding mechanical properties were also significantly enhanced.
Abstract Hydroxyapatite (HAP) structures have a great significance in the medicinal area because of its presence in bone and teeth and it provides structural inflexibility to the medium. This study deals with the synthesis and characterization of HAP biomaterials. It is prepared through wet chemical precipitation method at two different ranges of temperatures, 25°C-35 °C and 35°C-45 °C and is denoted as HAP1 and HAP2 respectively. Porous HAP provides a powerful bond to the bones, which interconn...
Last. P.K. Roy(IIT: Indian Institute of Technology (BHU) Varanasi)H-Index: 13
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Abstract Undoped and 3 mol% yttrium doped ZrO 2 –Al 2 O 3 composite powders with partially stabilized ZrO 2 (PSZ) content varying from 0 to 30 wt% were prepared by a co-precipitation route using inorganic precursors Al(NO 3 ) 3 , ZrOCl 2 and Y(NO 3 ) 3 . The precipitates were characterized by DTA and subsequently calcined at 1200 °C for 4 h to achieve fine grained composite powders. The calcined powders were characterized by FTIR and XRD. In order to enhance the sinterability, the calcined powde...
#1Pin-Yi Chen(MCUT: Ming Chi University of Technology)H-Index: 15
#2Sheng-Fen Wang(MCUT: Ming Chi University of Technology)H-Index: 2
Last. V. Hugo Schmidt(MSU: Montana State University)H-Index: 21
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Abstract This study highlights the effects of sintering temperature on the microstructures, densification, grain sizes/boundaries, calcium/phosphorus (Ca/P) ion ratios, mechanical and bioactive properties of biocompatible hydroxyapatite (HA) ceramics prepared via cold isostatic pressing. X-ray diffraction refinement analysis revealed that the phase ratios of hexagonal HA and secondary phases were sensitive to the sintering temperature. Grain sizes, densities, and shrinkages of the as-sintered HA...
Last. Zafer Evis(METU: Middle East Technical University)H-Index: 20
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Abstract Hydroxyapatite (HA) is a synthetic biomaterial resembling the composition of mammalian hard tissue and thus, it is widely employed as a bone graft material, hard tissue engineering scaffold and coating layer for metallic substrates. Biological apatite is non-stoichiometric in nature. It is composed of small crystals and characterized by poor crystallinity and relatively high solubility with respect to stoichiometric HA. Chemical compositions of these crystals consist of Ca, P and trace ...
Abstract In this study, a new method was developed for the deacidification of acidic papers, by using a deacidifying dispersion of oleic acid-modified magnesium oxide (MgO) nanoparticles in cyclohexane. We reported that oleic acid-modified MgO nanoparticles were prepared by using a surface modification method. The results showed that the carboxylic group of oleic acid could react with the hydroxyl group on the surface of nanoparticles and the reaction was esterification. MgO nanoparticles were t...
#2Youtao Xie(CAS: Chinese Academy of Sciences)H-Index: 24
Last. Kaili Lin(SJTU: Shanghai Jiao Tong University)H-Index: 3
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Abstract Maintaining the high crystallinity and tailoring the nano-structured surface of hydroxyapatite (HA) coatings on Ti-6Al-4V implants play critical roles in realizing their long-term service life span and fast osseointegration for biomedical implants. Herein, a nanorod structured HA (nHA) coating with a pure phase and high crystallinity was successfully developed by combining atmospheric plasma spraying (APS) with hydrothermal treatment (HT). The crystallinity degree of the plasma-sprayed ...
#1Bin He(CQMU: Chongqing Medical University)H-Index: 7
#2Jinqiu Zhao(CQMU: Chongqing Medical University)H-Index: 4
Last. Dianming Jiang(CQMU: Chongqing Medical University)H-Index: 18
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Abstract Bone tissue had moderate self-healing capabilities, but biomaterial scaffolds were required for the repair of some defects such as large bone defects. Peptide nanofiber scaffolds demonstrated important potential in regenerative medicine. Functional modification and controlled release of signal molecules were two significant approaches to increase the bioactivity of biofunctionalized peptide nanofiber scaffolds, but peptide scaffolds were limited by insufficient mechanical strength. Thus...
Last. Marc G.D. Geers(TU/e: Eindhoven University of Technology)H-Index: 24
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Abstract Additive manufacturing (AM) of ceramics through vat photopolymerization is a promising technique in which a ceramic filled photopolymer is selectively solidified in a layer-wise manner towards the final part geometry. Large scale adoption and optimization of AM for ceramics requires an in depth understanding of the process, which is pursued through a theoretical-numerical approach in this work. A modeling framework is proposed that integrates the coupled effect of four relevant physical...
Abstract Silk fibroin (SF) is a natural, biocompatible, and biodegradable polymer having a great potential for the successful regeneration of damaged bone tissue. In the present work, nanohydroxyapatite (nanoHA) was incorporated into SF polymer to form a bioactive composite hydrogel for applications as bone implants. The degradation and bioactive properties of SF/nanoHA composite hydrogels were evaluated. Additionally, biological investigations of human bone marrow stromal cells (hBMSCs) viabili...
#2Dongqin Xiao(North Sichuan Medical College)H-Index: 2
Last. Jie Weng(Southwest Jiaotong University)H-Index: 48
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Abstract Physical characteristics of bone tissue engineering scaffolds, including interconnectivity, microporosity, macroporosity, and pore geometry are known to play a crucial role in bone regeneration. In the present study, three-dimensional (3D) interconnected scaffolds were prepared by accumulating hydroxyapatite (HA) spheres in a titanium mesh tube (ф 1.5 × 3 cm). Three types of porous scaffolds were constructed using HA spheres with diameters of 1651–1981 μm, 830–1180 μm and a mixture of 1...
There is need for developing novel conductive polymers for Digital Light Processing (DLP) 3D printing. In this work, photorheology, in combination with Jacobs working curves, efficaciously predict the printability of polyaniline (PANI)/acrylate formulations with different contents of PANI and photoinitiator. The adjustment of the layer thickness according to cure depth values (Cd) allows printing of most formulations, except those with the highest gel point times determined by photorheology. In ...
#3Jin-Ho Kang(Chonnam National University)H-Index: 4
#3Jin-Ho Kang(Chonnam National University)H-Index: 15
Last. Sang-Won Park(Chonnam National University)H-Index: 4
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The design of zirconia-based scaffolds using conventional techniques for bone-regeneration applications has been studied extensively. Similar to dental applications, the use of three-dimensional (3D) zirconia-based ceramics for bone tissue engineering (BTE) has recently attracted considerable attention because of their high mechanical strength and biocompatibility. However, techniques to fabricate zirconia-based scaffolds for bone regeneration are in a stage of infancy. Hence, the biological act...
#1Wenxian Weng(PRC: China Medical University (PRC))H-Index: 2
#2Weiwei Wu(PRC: China Medical University (PRC))H-Index: 2
Last. Huazhe Yang(PRC: China Medical University (PRC))H-Index: 11
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Currently, biomimetic scaffold is one of the most promising strategies in the field of bone tissue engineering. Zirconia (ZrO2), as a kind of bioceramic material, has attracted much attention in biomimetic scaffolds due to its excellent biocompatibility, high mechanical strength and great chemical stability. A lot of work has been carried out to investigate the characteristics and applications of the zirconia-based biomimetic scaffolds. However, there is few work which can provide a systematic c...
The fabrication of scaffolds that precisely mimic the natural structure and physiochemical properties of bone is still one of the most challenging tasks in bone tissue engineering. 3D printing tech...
Last. Juan Ye(ZJU: Zhejiang University)H-Index: 11
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Abstract The orbital fracture regeneration and reconstruction is still a catastrophic challenge due to the extremely thin anatomical structure and different defect shapes in various clinical conditions. The conventional biomaterials and preparation technique are often inefficient in satisfying porous scaffold architecture designs with respect to their required structural stability and biological performances. Here we developed the ultrathin scaffolds with high- precision pore structure and appre...
Nowadays, the challenges of the industry increasingly demand the manufacture of complex shapes with great design flexibility without waste by 3D printing. Additive manufacturing, unlike traditional manufacturing techniques such as casting and machining, enables designers to rapid prototype while lowering operating costs and material waste during this process. In this way, understanding the current state of the literature related to additive manufacturing processes and the mechanical properties o...
#1Marcel F. Kunrath(PUCRS: Pontifícia Universidade Católica do Rio Grande do Sul)H-Index: 7
Abstract Surface treatments are decisive in the quality/speed of osseointegration and biointeraction in pure Titanium, Titanium alloys, and Zirconia-based implants. Nowadays, many technologies are available to accelerate this interaction, however, most are in the initial research stage, and their translation to implant printing techniques is complex. In this review article, the most applied methodologies for surface treatments with rapid osseointegration were summarized and the importance of cer...