Dysglycemia and Dyslipidemia Models in Nonhuman Primates: Part III. Type I or II Diabetogenic Effects of Streptozocin

Streptozocin (STZ), a naturally occurring glucosamine-nitrosourea compound, has been used for diabetogenic induction in animals for diabetic research due to its high toxicity to pancreatic beta cells. This study was to evaluate the diabetogenic effects of STZ by multiple low doses or by single high dose in normoglycemic Non-Human Primates (NHPs). Each monkey in the 1st group (n=6) was intravenously administered with 7.5 to 15 mg/kg STZ once...