Jiajun Gao
Internal medicineEndocrinologyAlbuminNonalcoholic fatty liver diseaseDosingDyslipidemiaInsulinProteinuriaDiabetic nephropathyLosartanCreatinineMetabolic syndromeCholineNephropathyPancreatic beta CellsStreptozocinToxicityLiver functionNormal dietPart iiiPhysiologyObesityDiabetes mellitusMedicineBiomarker (medicine)
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#1Jiajun GaoH-Index: 1
#2Xiaoli WangH-Index: 5
Last. Yong-Fu XiaoH-Index: 4
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ong-term hyperglycemia can impair renal microvessels and lead to diabetic nephropathy (DN). Early treatment can delay or prevent its progression. Efficacy of monoclonal antibody (mAb) therapies for human diseases can often be tested only in nonhuman primates (NHPs) but no other species due to lack of human mAb cross-reactivity. To test if DN in NHPs is similar to the human disease, this study analyzed the blood and urine biochemistry data from a large pool (n=129) of cynomolgus monkeys (Macacafa...
#1Jiajun GaoH-Index: 1
Last. Yong-Fu XiaoH-Index: 4
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Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome as an arising health issue globally. Obesity and diabetes seem coherent with high NAFLD occurrence. Currently, its underlying mechanism of cause and progression remains to be elicited and effective therapy is unavailable. Huge investment on studying its pathogenesis and innovative therapy is underway. As mechanistic studies are more difficult or unethical to be performed in humans, animal model that recap...
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#1Yongqiang LiuH-Index: 3
#2Jiajun GaoH-Index: 1
Last. Yong-Fu XiaoH-Index: 4
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Streptozocin (STZ), a naturally occurring glucosamine-nitrosourea compound, has been used for diabetogenic induction in animals for diabetic research due to its high toxicity to pancreatic beta cells. This study was to evaluate the diabetogenic effects of STZ by multiple low doses or by single high dose in normoglycemic Non-Human Primates (NHPs). Each monkey in the 1st group (n=6) was intravenously administered with 7.5 to 15 mg/kg STZ once every 2 to 4 weeks until successful induction of hyperg...
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