Original paper
Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1
Abstract
Inflammasome mediates the activation of caspase-1, which promotes the secretion of proinflammatory cytokines. In this work, we aimed to investigate whether natural compounds from a Traditional Chinese Medicine prescription called San-Huang-Xie-Xin-Tang exert its clinical efficacy by inhibiting inflammasome activation and the underlying mechanism. The inhibitory effects of compounds on caspase-1 were evaluated in recombinant expressed caspase-1...
Paper Details
Title
Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1
Published Date
Sep 1, 2019
Journal
Volume
147
Pages
104348 - 104348
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Notes
History