Pharmacological Research
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#1Chunfang Wang (CSU: Central South University)
#2Yating Wang (CSU: Central South University)
Last. Li Shen (CSU: Central South University)H-Index: 7
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Abstract null null Heart failure (HF) is still the leading cause of death worldwide, occurring with a variety of complex mechanisms. However, most intervention for HF cannot directly target the pathological mechanisms underlying cell damage in failing cardiomyocytes. Mitochondria are involved in many physiological processes, which is an important guarantee for normal heart function. Mitochondrial dysfunction is considered to be the critical node of the development of HF. Strict modulation of the...
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#1Alexander Kalinkovich (TAU: Tel Aviv University)H-Index: 6
#2Gregory Livshits (TAU: Tel Aviv University)H-Index: 40
On the cellular level, osteoporosis (OP) is a result of imbalanced bone remodeling, in which osteoclastic bone resorption outcompetes osteoblastic bone formation. Currently available OP medications include both antiresorptive and bone-forming drugs. However, their long-term use in OP patients, mainly in postmenopausal women, is accompanied by severe side effects. Notably, the fundamental coupling between bone resorption and formation processes underlies the existence of an undesirable secondary ...
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#2Elena Bresciani (University of Milano-Bicocca)H-Index: 11
Last. Antonio Torsello (University of Milano-Bicocca)H-Index: 36
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Androgens in women, as well as in men, are intrinsic to maintenance of (i) reproductive competency, (ii) cardiac health, (iii) appropriate bone remodeling and mass retention, (iii) muscle tone and mass, and (iv) brain function, in part, through their mitigation of neurodegenerative disease effects. In recognition of the pluripotency of endogenous androgens, exogenous androgens, and selected congeners, have been prescribed off-label for several decades to treat low libido and sexual dysfunction i...
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#1Hanyu Zhang (North Sichuan Medical College)H-Index: 6
Last. Zhangang XiaoH-Index: 21
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Gastric cancer (GC) development is a complex process displaying polytropic cell and molecular landscape within gastric tumor microenvironment (TME). Stromal cells in TME, including fibroblasts, endothelial cells, mesenchymal stem cells, and various immune cells, support tumor growth, metastasis, and recurrence, functioning as the soil for gastric tumorigenesis. Importantly, exosomes secreted by either stromal cells or tumor cells during tumor-stroma crosstalk performed as crucial transporter of ...
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#1Zahra Memariani (Babol University of Medical Sciences)H-Index: 9
#2Syed Qamar Abbas (Sarhad University of Science & IT, Ring Road (Hayatabad Link) Peshawar)H-Index: 1
Last. Aroona Chabra (Mazandaran University of Medical Sciences)H-Index: 11
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Although the rates of many cancers are controlled in Western countries, those of some cancers, such as lung, breast, and colorectal cancer are currently increasing in many low- and middle-income countries due to increases in risk factors caused by development and societal problems. Additionally, endogenous factors, such as inherited mutations, steroid hormones, insulin, and insulin-like growth factor systems, inflammation, oxidative stress, and exogenous factors (including tobacco, alcohol, infe...
5 CitationsSource
#1Xiao-Wen Ding (AU: Auburn University)
#2Megan Robinson (AU: Auburn University)
Last. Jeganathan Ramesh Babu (AU: Auburn University)H-Index: 17
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Diabetes and Alzheimer's disease are common chronic illnesses in the United States and lack clearly demonstrated therapeutics. Mitochondria, the "powerhouse of the cell", is involved in the homeostatic regulation of glucose, energy, and reduction/oxidation reactions. The mitochondria has been associated with the etiology of metabolic and neurological disorders through a dysfunction of regulation of reactive oxygen species. Mitochondria-targeted chemicals, such as the Szeto-Schiller-31 peptide, h...
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#1Carla Carnovale (University of Milan)H-Index: 18
#2F. Parisi (Boston Children's Hospital)H-Index: 9
Last. Gianluca Cammarata (University of Milan)
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Women of childbearing age are largely affected by several autoimmune disorders (the estimates range between 1.5 and 10 per 10,000). The increasing number of effective biological agents has dramatically revolutionized the treatment of these clinical conditions, ameliorating the patient's quality of life. The use of these agents by women during pregnancy is growing to ensure the disease activity control and avoid adverse health outcomes. However, for many newer biological agents, the degree of inf...
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#1Shahin Aghamiri (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 5
#2Farshid Zandsalimi (Tehran University of Medical Sciences)H-Index: 2
Last. Hossein Ghanbarian (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 16
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Breast cancer is the most common and deadliest cancer in women worldwide. Although notable advances have been achieved in the treatment of breast cancer, the overall survival rate of metastatic breast cancer patients is still considerably low due to the development of resistance to breast cancer chemotherapeutic agents and the non-optimal specificity of the current generation of cancer medications. Hence, there is a growing interest in the search for alternative therapeutics with novel anticance...
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#1Oluwatobiloba Osikoya (University of North Texas Health Science Center)H-Index: 3
#2Spencer C. Cushen (University of North Texas Health Science Center)H-Index: 4
Last. Styliani Goulopoulou (University of North Texas Health Science Center)H-Index: 24
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Abstract null null Uterine perivascular adipose tissue (PVAT) contributes to uterine blood flow regulation in pregnancy, at least in part, due to its effects on uterine artery reactivity. We tested the hypothesis that uterine PVAT modulates the balance between the contribution of nitric oxide synthase (NOS)- and cyclooxygenase (COX)-dependent pathways to acetylcholine (ACh)-induced relaxation in isolated uterine arteries. Concentration-response curves to ACh (1 nM – 30 µM) were performed on uter...
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#1Ya-Ting Wang (Beijing University of Chinese Medicine)H-Index: 2
#2Xiao-Le Wang (Beijing University of Chinese Medicine)H-Index: 2
Last. Yi Zhang (Beijing University of Chinese Medicine)H-Index: 10
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Abstract null null Major depressive disorder (MDD) is severely prevalent, and conventional monoaminergic antidepressants gradually exhibit low therapeutic efficiency, especially for patients with treatment-resistant depression. A neuroplasticity hypothesis is an emerging advancement in the mechanism of depression, mainly expressed in the glutamate system, e.g., glutamate receptors and signaling. Dysfunctional glutamatergic neurotransmission is currently considered to be closely associated with t...
1 CitationsSource
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