Background: Human Metapneumovirus (hMPV) is a negative single-stranded RNA virus. Infection by hMPV mainly affects the pediatric population and can cause upper or lower respiratory tract pathologies which can develop life threating complications. This study was carried out between 2009 and 2010 in a high complexity national hospital in Lima, Peru. The time frame corresponds to the pandemic of influenza A H1N1. Methods: A prospective study was performed between September 2009 and September 2010. Patients with a clinical diagnosis suggestive of an acute respiratory infection were included. RT-PCR was utilized to attain the amplification and identification of the hMPV. Results: A total of 539 samples were analyzed from patients with a clinical context suggestive of an acute respiratory tract infection. Of these samples 73, (13.54%) were positive for hMPV. Out of the positive cases, 63% were under one year old, and increased to nearly 80% when considering children younger than two years old. Cough was the most frequent symptom presented by our population with a number of 62 cases (84.93%). Viral seasonality was also established, noting its predominance during the months of summer in the southern hemisphere. The infection by hMPV has an important prevalence in Peru. It mainly affects children under one year old and should be considered an important differential diagnosis in a patient with an acute respiratory infection.
: Syndromic diagnosis by multiplex nucleic acid amplification tests is the most practical approach to respiratory tract infections since the symptoms are rarely agent-specific. The aim of this study was to investigate the respiratory viruses in children admitted to a university hospital with acute respiratory tract infection during the last 8 years by a multiplex polymerase chain reaction (PCR) assay. A total of 3162 respiratory samples collected from children between April 2011 and April 2018 t...
Viral respiratory tract diseases pose serious public health problems. Our ability to predict and thus, be able to prepare for outbreaks is strained by the complex factors driving the prevalence and severity of these diseases. The abundance of diseases and transmission dynamics of strains are not only affected by external factors, such as weather, but also driven by interactions among viruses mediated by human behavior and immunity. To untangle the complex out-of-phase annual and biennial pattern...
Human metapneumovirus (HMPV), a paramyxovirus identified in 2001, is a leading cause of acute respiratory disease worldwide [1, 2]. In high-risk populations, HMPV causes significant morbidity and mortality [3, 4]. No vaccines or therapeutics specifically target HMPV, and nonspecific therapies such as ribavirin and intravenous immunoglobulin have limited efficacy [5]. HMPV has 4 subgroups, which vary in prevalence but cause similar disease [6, 7]. Although the subgroups are relatively conserved, ...
A human monoclonal antibody has been identified which can cross-neutralize both human respiratory syncytial virus (HRSV) and human metapneumovirus (HMPV), demonstrating that a single monoclonal antibody can target different viruses, a discovery that may lead to the creation of new therapeutics and vaccines.
BackgroundThe inpatient and outpatient burden of human metapneumovirus (HMPV) infection among young children has not been well established. MethodsWe conducted prospective, population-based surveillance for acute respiratory illness or fever among inpatient and outpatient children less than 5 years of age in three U.S. counties from 2003 through 2009. Clinical and demographic data were obtained from parents and medical records, HMPV was detected by means of a reverse-transcriptase polymerase-cha...
To the Editor—Viral respiratory infections represent a frequent cause of intensive care unit (ICU) admissions in children and impose a considerable burden worldwide [1]. The main pathogens are respiratory syncytial virus (RSV) and seasonal influenza. Human metapneumovirus (hMPV) is an emerging pathogen of the Paramyxoviridae family causing acute bronchiolitis-like respiratory illness in children [2]. Williams et al [2] have recently reported an annual rate of hMPV-associated hospitalizations of ...
Human metapneumovirus (hMPV), a recently discovered paramyxovirus, is thought to be primarily a winter-spring pathogen affecting young children with a clinical presentation similar to that of respiratory syncytial virus. In June-July 2006, a respiratory outbreak in a long-term-care facility was reported to the local health department and investigated. Surveillance identified 26 residents and 13 staff with acute respiratory illness; 8 residents (31%) developed radiographically confirmed pneumonia...
Background. Human metapneumovirus (hMPV) is a newly described paramyxovirus that is mainly associated with bronchiolitis in children. We sought to describe the epidemiological, virological, and histopathological findings associated with a large outbreak of hMPV infection in a long-term care facility. Methods. An investigation of the outbreak was performed by public health authorities, who used standardized questionnaires to collect relevant clinical information from all residents of the facility...
The molecular epidemiologic profile of human metapneumovirus (hMPV) infection has likely been skewed toward certain genetic subtypes because of assay-design issues, and no comprehensive studies have been conducted to date. Here, reverse-transcription polymerase chain reaction was used to screen 10,319 specimens from patients presenting to hospitals with suspected respiratory tract infections during 2001 - 2004. After analysis of 727 Australian hMPV strains, 640 were assigned to 1 of 4 previously...
Background. Infection with the newly discovered human metapneumovirus (hMPV) may lead to hospitalization of children with lower respiratory tract infection (LRTI), although the pathogenesis thereof remains to be elucidated. Methods. This hypothesis-generating study involved a cohort of children randomized to receive 9-valent conjugate pneumococcal vaccine or placebo and who were tested for hMPV infection when hospitalized for LRTI. By use of a nested reverse-transcription polymerase chain reacti...
Acute respiratory tract infections (ARTI) contribute to morbidity and mortality in children globally. Viruses including human metapneumovirus (hMPV) account for most ARTIs. The virus causes upper and lower respiratory tract infections mostly in young children and contributes to hospitalization of individuals with asthma,chronic obstructive pulmonary diseases and cancer. Moreover, hMPV pauses a considerable socio-economic impact creating a substantial disease burden wherever it has been studied, ...
Cocuklarda toplumdan kazanilmis akut sonulum yolu enfeksiyonuna neden olan Human Metapneumovirus (HMPV) ilk kez 2001 yilinda izole edilmistir. Hafif ust solunum yolu enfeksiyonundan bronsolit ve pnomoniye kadar farkli spektrumda hastalik olusturabilmektedir. Immun sistemi baskilanmis hastalarda ciddi klinik tablolarin olusmasina ve bu hastalarin hastaneye yatisina sebep olabilmektedir. Calismamizda tekli ve ko-enfeksiyon seklinde tespit edilen HMPV bir yillik sonuclari geriye yonelik tarandi ve ...
