Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin
Abstract
Obesity and dyslipidemia can be associated with cellular senescence, and may impair kidney function. However, whether senescence contributes to renal dysfunction in these conditions remains unclear. Quercetin is an abundant dietary flavonoid that selectively clears inhibiting PI3K/AKT and p53/p21/serpines and inducing apoptosis. We hypothesized that high-fat-diet-induced obesity causes renal senescence, which would be mitigated by...
Paper Details
Title
Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin
Published Date
Jul 15, 2019
Journal
Volume
213
Pages
112 - 123
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