Translational Research
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#1Joana Barroso (NU: Northwestern University)H-Index: 2
#2Paulo Branco (NU: Northwestern University)H-Index: 5
Last. Apkar Vania Apkarian (NU: Northwestern University)H-Index: 15
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Chronic pain is a leading cause of disability worldwide and its prevalence is likely to increase over the next decades. Treatment for chronic pain remains insufficient and therapeutical advances have not made comparable progress with that for many chronic disorders, thus amplifying the concern on the future burden of the disease. At the same time, and even after decades of intense research, the underlying pathophysiology of chronic pain remains minimally understood. We believe advancing our curr...
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#1Afra I. Toma (Georgia Institute of Technology)
#2Julia M. Fuller (Emory University)
Last. Steven L. Goudy (Georgia Institute of Technology)
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Following injury, the oral mucosa undergoes complex sequences of biological healing processes to restore homeostasis. While general similarities exist, there are marked differences in the genomics and kinetics of wound healing between the oral cavity and cutaneous skin. The lack of successful therapy for oral mucosal wounds has influenced clinicians to explore alternative treatments and potential autotherapies to enhance intraoral healing. The present in-depth review discusses current gold stand...
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#1Alexander N. Garcia (UA: University of Arizona)H-Index: 2
#2Nancy Casanova (UA: University of Arizona)H-Index: 8
Last. Mia Valdez (UA: University of Arizona)
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Therapeutic strategies to prevent or reduce the severity of radiation pneumonitis are a serious unmet need. We evaluated extracellular nicotinamide phosphoribosyltransferase (eNAMPT), a damage-associated molecular pattern protein (DAMP) and Toll-Like Receptor 4 (TLR4) ligand, as a therapeutic target in murine radiation pneumonitis. Radiation-induced murine and human NAMPT expression was assessed in vitro, in tissues (IHC, biochemistry, imaging), and in plasma. Wild type C57Bl6 mice (WT) and Namp...
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#1Cambrian Y. Liu (U of C: University of Chicago)
#2Candace M. Cham (U of C: University of Chicago)
Last. Eugene B. Chang (U of C: University of Chicago)H-Index: 84
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Abstract null null Patients with one of the many chronic inflammatory disorders broadly classified as inflammatory bowel disease (IBD) now have a diverse set of immunomodulatory therapies at their disposal. Despite these recent medical advances, complete sustained remission of disease remains elusive for most patients. The full healing of the damaged intestinal mucosa is the primary goal of all therapies. Achieving this requires not just a reduction of the aberrant immunological response, but al...
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#1Hiroki Ishii (Jichi Medical University)H-Index: 6
#2Shohei Kaneko (Jichi Medical University)H-Index: 4
Last. Yoshiyuki Morishita (Jichi Medical University)H-Index: 11
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The microRNAs (miRNAs) that can regulate diabetic kidney disease (DKD) have not been fully characterized. The aim of this study was to identify the miRNAs that affect DKD and could be used as specific biomarkers or therapeutic agents. First, kidney tissues from two DKD mouse models and control mice were screened for differences in miRNA expression by microarray analysis followed by quantitative real-time reverse transcription-PCR. Six miRNAs were differentially expressed from controls in both DK...
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#1Lai Ying-Ju (CGU: Chang Gung University)
#2Winston W.-Y. Kao (UC: University of Cincinnati)H-Index: 23
Last. Pao-Hsien Chu (Memorial Hospital of South Bend)H-Index: 20
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Pulmonary arterial hypertension (PAH) is caused by progressive extracellular matrix disorganization and increased pulmonary vascular cell proliferation. Lumican is a member of the small leucine-rich proteoglycan (SLRP) family that controls cell proliferation, and is a potential endogenous modulator of TGF-β signaling pathway. We show that the decreased lumican protein levels in pulmonary arterial smooth muscle cells (PASMCs) is related to the vascular remodeling and stiffening observed in PAH. T...
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#1Amanda E. Louiselle (University of Colorado Denver)H-Index: 2
#2Stephen Niemiec (University of Colorado Denver)H-Index: 3
Last. Kenneth W. Liechty (University of Colorado Denver)H-Index: 43
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Diabetes mellitus is a costly disease and nearly one-third of these costs are attributed to management of diabetic foot disease including chronic, non-healing, diabetic foot ulcers. Therefore, much effort has been placed into understanding the pathogenesis of diabetic wounds and novel therapeutics. A relatively new area of interest has been macrophage polarization and its role in diabetic wound healing. Diabetic wounds show dysregulated and persistent M1 (pro-inflammatory) macrophage polarizatio...
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#1Christian Bime (UA: University of Arizona)H-Index: 14
#2Nancy Casanova (UA: University of Arizona)H-Index: 8
Last. Joe G.N. Garcia (UA: University of Arizona)H-Index: 114
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Approximately 15%-20% of patients infected with SARS-CoV-2 coronavirus (COVID-19) progress beyond mild and self-limited disease to require supplemental oxygen for severe pneumonia; 5% of COVID-19-infected patients further develop acute respiratory distress syndrome (ARDS) and multiorgan failure. Despite mortality rates surpassing 40%, key insights into COVID-19-induced ARDS pathology have not been fully elucidated and multiple unmet needs remain. This review focuses on the unmet need for effecti...
1 CitationsSource
#1Bettina Leber (Medical University of Graz)H-Index: 16
#2Irina Balázs (Medical University of Graz)
Last. Vanessa Stadlbauer (Medical University of Graz)H-Index: 35
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Abstract Chronic hepatitis C virus infection is characterized by multiple extra-hepatic manifestations. Innate immune dysfunction and hemolysis are symptoms which might be associated with each other. We investigated the impact of direct acting antivirals on neutrophil function and its connection to hemolysis. In this prospective study, 85 patients with or without cirrhosis and 21 healthy controls were included. Patients’ blood samples were taken at baseline, at the end of therapy and at follow-u...
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#1Ruth Fernandez-Ruiz (NYU: New York University)H-Index: 6
#2Jacqueline L Paredes (NYU: New York University)H-Index: 3
Last. Timothy B. Niewold (NYU: New York University)H-Index: 62
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As the world navigates the coronavirus disease 2019 (COVID-19) pandemic, there is a growing need to assess its impact in patients with autoimmune rheumatic diseases, such as systemic lupus erythematosus (SLE). Patients with SLE are a unique population when considering the risk of contracting COVID-19 and infection outcomes. The use of systemic glucocorticoids and immunosuppressants, and underlying organ damage from SLE are potential susceptibility factors. Most patients with SLE have evidence of...
3 CitationsSource
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Endocrinology
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