An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

Cell64.50
Volume: 178, Issue: 4, Pages: 835
Published: Aug 8, 2019
Abstract
Diverse genetic, epigenetic, and developmental programs drive glioblastoma, an incurable and poorly understood tumor, but their precise characterization remains challenging. Here, we use an integrative approach spanning single-cell RNA-sequencing of 28 tumors, bulk genetic and expression analysis of 401 specimens from the The Cancer Genome Atlas (TCGA), functional approaches, and single-cell lineage tracing to derive a unified model of cellular...
Paper Details
Title
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
Published Date
Aug 8, 2019
Journal
Volume
178
Issue
4
Pages
835
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