INTRODUCTION: The aim of this study was to evaluate the association between fetal ultrasound and newborn biometry and adiposity measures in the setting of maternal obesity. MATERIAL AND METHODS: The study population involved 845 overweight or obese pregnant women, who participated in the Standard Care Group of the LIMIT randomised trial (ACTRN12607000161426, 9/03/2007). At 36 weeks gestation, fetal biometry, estimated fetal weight (EFW) and adiposity measures including mid-thigh fat mass (MTFM), subscapular fat mass (SSFM), and abdominal fat mass (AFM) were undertaken using ultrasound. Neonatal anthropometric measurements obtained after birth included birthweight, head circumference (HC), abdominal circumference (AC) and skinfold thickness measurements (SFTM) of the subscapular region and abdomen. RESULTS: At 36 weeks gestation, every 1 g increase in EFW was associated with a 0.94 g increase in birthweight (95% CI 0.88-0.99; P < 0.001). For every 1 mm increase in the fetal ultrasound measure, there was a 0.69 mm increase in birth HC (95% CI 0.63-0.75, P < 0.001) and 0.69 mm increase in birth AC (95% CI 0.60-0.79, P < 0.001). Subscapular fat mass in the fetus and the newborn (0.29 mm, 95% CI 0.20-0.39, P < 0.001) were moderately associated, but AFM measurements were not (0.06 mm, -0.03 to 0.15, P = 0.203). There is no evidence that these relationships differed by maternal body mass index. CONCLUSION: In women who are overweight or obese, fetal ultrasound accurately predicts neonatal HC and AC along with birthweight.
Last. Jennie Louise(University of Adelaide)H-Index: 11
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Introduction Obesity represents a significant health burden, and WHO recognises the importance of preventing weight gain and subsequent development of obesity among adults who are within the healthy weight range. Women of reproductive age have demonstrated high rates of weight gain during pregnancy placing them at risk of becoming overweight or obese. We will evaluate the effects of dietary and physical activity advice on maternal, fetal and infant health outcomes, among pregnant women of normal...
Importance Despite the increasing prevalence of pregravid obesity, systematic evaluation of the association of maternal obesity with fetal growth trajectories is lacking. Objective To characterize differences in fetal growth trajectories between obese and nonobese pregnant women, and to identify the timing of any observed differences. Design, Setting, and Participants The Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies–Singletons study enrolle...
#1Satoru Ikenoue(UCI: University of California, Irvine)H-Index: 9
#2Feizal Waffarn(UCI: University of California, Irvine)H-Index: 21
Last. Pathik D. Wadhwa(UCI: University of California, Irvine)H-Index: 66
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SummaryBackground Newborns exhibit substantial variation in gestational age-adjusted and sex-adjusted fat mass proportion. The antecedent characteristics of fetal body composition that are associated with newborn fat mass proportion are poorly understood. Objective The aim of this study was to determine whether a composite measure of fetal fat mass is prospectively associated with newborn adiposity. Methods In a longitudinal study of 109 low-risk pregnancies, fetal ultrasonography was performed ...
#1Kelly S. Gibson(Case Western Reserve University)H-Index: 11
#2Bradley Stetzer(Case Western Reserve University)H-Index: 14
Last. Stephen A. Myers(Case Western Reserve University)H-Index: 7
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To compare the accuracy of 2-dimensional (2D) and 3-dimensional (3D) fetal measurements for prediction of birth weight Z score and neonatal adiposity (percent body fat) in the setting of suspected fetal macrosomia.We conducted a prospective observational study of term singleton pregnancies with suspected macrosomia. Patients were enrolled on admission to labor and delivery and underwent sonographic examinations. Within 48 hours of delivery, neonatal anthropometric measurements were obtained.Thir...
Last. Jodie M Dodd(University of Adelaide)H-Index: 50
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Objective To report the influence of maternal overweight and obesity on fetal growth and adiposity and effects of an antenatal dietary and lifestyle intervention among these women on measures of fetal growth and adiposity as secondary outcomes of the LIMIT Trial. Design Randomised controlled trial. Setting Public maternity hospitals in metropolitan Adelaide, South Australia. Population Pregnant women with a body mass index ≥ 25 kg/m2, and singleton gestation between 10+0 and 20+0 weeks. Methods ...
Objective To evaluate the effect of providing antenatal dietary and lifestyle advice on neonatal anthropometry, and to determine the inter-observer variability in obtaining anthropometric measurements. Design Randomised controlled trial. Setting Public maternity hospitals across metropolitan Adelaide, South Australia. Population Pregnant women with a singleton gestation between 10+0 and 20+0 weeks, and body mass index (BMI) ≥25 kg/m2. Methods Women were randomised to either Lifestyle Advice (com...
Objective To evaluate the value of third trimester ultrasound (estimated fetal weight, cheek-to-cheek diameter, sectional Wharton's jelly area, sectional areas and fractional volumes in extremities) to predict birth weight and cord biochemical markers at birth (leptin, insulin, c-peptide, IGF1, erythropoietin and ferritin) in diabetic pregnancies. Method Prospective study in 49 patients with gestational diabetes. An ultrasound was performed between 32 and 34 weeks. Clinical data were collected, ...
AbstractObjective: Our objective was to determine if early pregnancy urinary metabolomic profiles could predict fetal adiposity and macrosomia.Methods: This is a prospective study of 50 healthy women in their second pregnancy. Fasting urine samples taken during early pregnancy were analyzed using NMR spectroscopy. Maternal glucose and insulin were measured in early pregnancy and at 28 weeks and the HOMA index for insulin resistance calculated. At 34 weeks ultrasound assessed fetal anthropometry ...
Last. Mark Walker(Ottawa Hospital Research Institute)H-Index: 103
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Objective. To determine a precise estimate for the contribution of maternal obesity to macrosomia. Data Sources. The search strategy included database searches in 2011 of PubMed, Medline (In-Process & Other Non-Indexed Citations and Ovid Medline, 1950–2011), and EMBASE Classic
Last. Sven Cnattingius(Karolinska University Hospital)H-Index: 102
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Objective To investigate associations between maternal overweight and obesity and infant mortality outcomes, including cause-specific mortality. Design Population based cohort study. Setting and participants 1 857 822 live single births in Sweden 1992–2010. Main outcome measures Associations between maternal body mass index (BMI) in early pregnancy and risks of infant, neonatal, and postneonatal mortality, overall and stratified by gestational length and by causes of infant death. Odds ratios we...
BACKGROUND In response to the challenges of assessing fetal growth in obese women, guidelines recommend routine third trimester ultrasound scans. AIM The aim of this study was to assess the diagnostic performance of this routine scan in obese women (body mass index (BMI) ≥ 35 kg/m2 ). METHODS A retrospective cohort study of 1008 pregnancies with maternal BMI ≥ 35 kg/m2 born after 37 weeks gestation at a Victorian hospital from 2015 to 2017. Multiple pregnancies and those affected by diabetes wer...
#1Marva Bergman(Shaare Zedek Medical Center)H-Index: 1
#2Orna Reichman(Shaare Zedek Medical Center)H-Index: 9
Last. Hen Y. Sela(Shaare Zedek Medical Center)H-Index: 9
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Fetal growth restriction is suspected when the estimated fetal weight is <10th percentile for gestational age. Using a regional sonographic estimated fetal weight growth curve to diagnose fetal gro...
