Berberine improves intestinal epithelial tight junctions by upregulating A20 expression in IBS-D mice
Abstract
To investigate effects of berberine exerts on A20 expression and regulation of intestinal epithelial tight junctions via the TNF-α-NF-κB-MLCK pathway in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D). C57BL/6 wild type (WT) and A20 IEC-KO mice (48 each) were randomly divided into normal control (NC), model control (MC), rifaximin and berberine groups (12 mice per group). An experimental model of IBS-D was established using 4% acetic acid...
Paper Details
Title
Berberine improves intestinal epithelial tight junctions by upregulating A20 expression in IBS-D mice
Published Date
Oct 1, 2019
Volume
118
Pages
109206 - 109206
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