Review paper
Is prodrug design an approach to increase water solubility?
Abstract
Water solubility has been identified as a critical parameter and the main responsible by affecting poor performance of oral drug delivery. Poorly soluble drugs can originate unsatisfactory ADME properties leading to low oral bioavailability, insufficient chemical stability, low half-life, fast pre-systemic metabolism and difficulties in formulation. In this context, the prodrug design is an alternative in order to improve physicochemical,...
Paper Details
Title
Is prodrug design an approach to increase water solubility?
Published Date
Sep 1, 2019
Volume
568
Pages
118498 - 118498
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