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Original paper

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Nature50.50
Volume: 572, Issue: 7768, Pages: 254 - 259
Published: Jul 17, 2019
Abstract
Patients with acute myeloid leukaemia (AML) often achieve remission after therapy, but subsequently die of relapse1 that is driven by chemotherapy-resistant leukaemic stem cells (LSCs)2,3. LSCs are defined by their capacity to initiate leukaemia in immunocompromised mice4. However, this precludes analyses of their interaction with lymphocytes as components of anti-tumour immunity5, which LSCs must escape to induce cancer. Here we demonstrate...
Paper Details
Title
Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion
Published Date
Jul 17, 2019
Journal
Volume
572
Issue
7768
Pages
254 - 259
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