Chrysin suppress immune responses and protects from experimental autoimmune encephalomyelitis in mice
Abstract
We investigated the effects of chrysin in the experimental autoimmune encephomyelitis (EAE), a multiple sclerosis (MS) animal model. EAE was induced using myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide in C57BL/6 mice. Chrysin reduced weight loss, attenuated clinical signs and blunted the EAE-induced increase in histone deacetylase (HDCA) activity, glycogen synthase kinase-3β (GSK-3β) levels and pro-inflammatory cytokine levels as well...
Paper Details
Title
Chrysin suppress immune responses and protects from experimental autoimmune encephalomyelitis in mice
Published Date
Oct 1, 2019
Journal
Volume
335
Pages
577007 - 577007
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