Journal of Neuroimmunology
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#1Akio Kimura (Gidai: Gifu University)H-Index: 19
#2Shinei Kato (Gidai: Gifu University)H-Index: 1
Last. Takayoshi Shimohata (Gidai: Gifu University)H-Index: 33
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Abstract null null We report two patients with meningoencephalomyelitis without evidence of extra central nervous system (CNS) involvement. Brain MRI showed linear perivascular radial gadolinium enhancement patterns and spinal cord MRI showed longitudinal extensive T2-hyperintensity lesions. Pathological findings from brain biopsies were angiocentric T-cell predominant lymphoid infiltrates that lacked Epstein–Barr virus-positive atypical B cells. The patients were initially suspected to have iso...
#1Juichi Fujimori (Tohoku Pharmaceutical University)H-Index: 11
#2Kouichi Miyazawa (Tohoku Pharmaceutical University)H-Index: 1
Last. Ichiro Nakashima (Tohoku Pharmaceutical University)H-Index: 58
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Vaccine administration may be involved in the development of some central nervous system demyelinating diseases. The COVID-19 vaccine is being administered to the entire population, but to date, little association between vaccination and the risk of developing multiple sclerosis (MS) has been suggested, and only a few case reports have been published. Here, we present a 40-year-old woman who developed cervical myelitis after receiving the COVID-19 vaccine. Myelitis was considered the initial cli...
#1Takayuki Nagano (Hyogo College of Medicine)H-Index: 5
#2Naohiko Tsuda (Hyogo College of Medicine)
Last. Shinya H. Kimura (Hyogo College of Medicine)H-Index: 4
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Abstract null null Prostaglandin E2 (PGE2) plays pivotal roles in controlling microglial activation with the EP2 receptor, a PGE2 receptor subtype. Activated microglia are often reported to increase cyclooxygenase (COX)-2 expression, followed by PGE2 production, but it is unclear whether extracellular PGE2 is involved in microglial PGE2 synthesis. In the present study, we report that PGE2 increases COX-2 protein in microglia. In a culture system, PGE2 at 10−6 M for 3 h increased COX-2 and micros...
#1Georgios Katsipis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 3
#2Elena E. Tzekaki (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 2
Last. Anastasia A. Pantazaki (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 31
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Abstract null null Glial fibrillary acidic protein (GFAP) is the main constituent of the astrocytic cytoskeleton, overexpressed during reactive astrogliosis–a hallmark of Alzheimer's Disease (AD). GFAP and established biomarkers of neurodegeneration, inflammation, and apoptosis have been determined in the saliva of amnestic-single-domain Mild Cognitive Impairment (MCI) (N = 20), AD (N = 20) patients, and cognitively healthy Controls (N = 20). Salivary GFAP levels were found significantly decreas...
#1Eric A. Sribnick (Nationwide Children's Hospital)H-Index: 3
#2Timothy Warner (The Research Institute at Nationwide Children's Hospital)
Last. Mark W. Hall (Nationwide Children's Hospital)H-Index: 36
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Abstract null null Background null Traumatic brain injury (TBI) is a common cause of morbidity and mortality. We have previously shown that TBI with a concurrent extra-cranial injury reliably leads to post-injury suppression of the innate immune system, but the impact of this injury on the adaptive immune system is unknown. We present data showing that combined injury reduced immune response as assayed in both blood and spleen samples and that these changes parallel apoptosis in the spleen. To a...
#1Naser-Aldin Lashgari (IAU: Islamic Azad University)H-Index: 4
#2Nazanin Momeni Roudsari (IAU: Islamic Azad University)H-Index: 5
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 111
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Parkinson's disease (PD) is a neurodegenerative disorder in which inflammation and oxidative stress play key etiopathological role. The pathology of PD brain is characterized by inclusions of aggregated α-synuclein (α-SYN) in the cytoplasmic region of neurons. Clinical evidence suggests that stimulation of pro-inflammatory cytokines leads to neuroinflammation in the affected brain regions. Upon neuroinflammation, the Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) sign...
#1Kathryn E. Reynolds (McMaster University)H-Index: 1
#2Victoria Krasovska (McMaster University)H-Index: 1
Last. Angela L. Scott (McMaster University)H-Index: 4
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The symptoms of Fragile X syndrome (FXS) are driven in part by abnormal glial-mediated function. FXS astrocytes release elevated levels of immune-related factors interleukin-6 (IL-6) and tenascin C (TNC), and also demonstrate increased purinergic signaling, a pathway linked to signaling factor release. Here, in cortical astrocytes from the Fmr1 knockout (KO) FXS mouse model, purinergic agonism enhanced TNC secretion and STAT3 phosphorylation, two processes linked to elevated IL-6 secretion in FX...
Abstract null null We present a patient with positive medium titer MOG-IgG and progressive neurological decline whose clinical and radiological phenotype were not consistent with MOG-IgG associated disorder and ultimately received a diagnosis of glioblastoma after brain biopsy and died 4 weeks later. This represents an important topic with a very high frequency of MOG-IgG testing in clinical practice. Due to this there are increasing reports of MOG-IgG positivity in atypical clinical phenotypes,...
Eculizumab is a recombinant humanized monoclonal antibody that targets the complement protein C5, inhibiting its cleavage into C5a and C5b and ultimately preventing the formation of C5b-9 membrane attack complex (MACs), thereby protecting the neuromuscular junction from the damage of complement activation. In 2017, eculizumab became the second FDA-approved medication for AchR-positive generalized myasthenia gravis (gMG) patients based on the successful results of a randomized, double-blinded, pl...
#1Negar Molazadeh (Harvard University)
#2Angeliki Filippatou (Johns Hopkins University)H-Index: 10
Last. Elias S. Sotirchos (Johns Hopkins University)H-Index: 18
view all 5 authors...
Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) and aquaporin-4 IgG seropositive neuromyelitis optica spectrum disorder (AQP4-IgG+ NMOSD) are generally considered to be relapsing disorders, without clinical progression or subclinical disease activity outside of clinical relapses, in contrast to multiple sclerosis (MS). With advances in the diagnosis and treatment of these conditions, prolonged periods of remission without relapses can be achieved, and the question of whether progres...
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