Abstract Three new sesquilignans, zijusesquilignans A-C ( 1 – 3 ), together with fifteen known compounds ( 4 – 18 ), were isolated from fruits of Ziziphus jujuba var. inermis Rehder (Rhamnaceae) . Their chemical structures were established using spectroscopic analyses including 1D- and 2D-NMR, HR-EIMS, and ECD spectra. These compounds were assessed for their inhibitory effects on nitric oxide (NO) production. Of these compounds, 1 – 3 and 17 displayed inhibitory effects on NO production, with IC 50 values ranging from 18.1 to 66.4 μM. Pretreatment with 1 and 17 significantly suppressed LPS-induced expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein in cells. Moreover, compounds 1 – 3 , 7 , 9 , and 17 exhibited cytotoxic activities against three human tumor cell lines, with IC 50 values ranging from 8.4 to 44.9 μM.
#1Minna Shin(UPR-RP: UPRRP College of Natural Sciences)H-Index: 1
#2Bo-Mi Lee(DCU: Catholic University of Daegu)H-Index: 2
Last. Jeong-Hyung Lee(UPR-RP: UPRRP College of Natural Sciences)H-Index: 24
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Ziziphus jujuba var. inermis Rehder is an edible fruit-producing species of the Rhamnaceae family. In the present study, we isolated eight triterpenoids (1–8) from the fruits of Z. jujuba var. inermis and evaluated their apoptotic cell-death-inducing activities in human cancer cell lines (A549, PC-3, and MDA-MB-231). The structures of compounds 1–8 were determined by spectroscopic methods. Among these, four isomers of coumaroyl alphitolic acid showed potent cytotoxic activities on these cancer c...
#2Thao Quyen Cao(CUA: The Catholic University of America)H-Index: 4
Last. Byung Sun Min(CUA: The Catholic University of America)H-Index: 53
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Five new compounds, 9,3′-dimethoxyhierochin A (1), 6-oxo-trans-neocnidilide (2), (±)-(3E)-trans-6-hydroxy-7-methoxydihydroligustilide (3), (±)-cnidiumin (4), and 6-(1-oxopentyl)-salicylic acid methyl ester (5), together with twenty known compounds (6–25), were isolated from the rhizome of Cnidium officinale. The chemical structures of new compounds were established by NMR spectroscopic techniques, mass spectrometry, Mosher’s method, and CD spectrum. Their anti-inflammatory activities were evalua...
#1Phi-Long Tran(UPR-RP: UPRRP College of Natural Sciences)H-Index: 3
#2Phuong Thao Tran(UPR-RP: UPRRP College of Natural Sciences)H-Index: 8
Last. Jeong-Hyung Lee(UPR-RP: UPRRP College of Natural Sciences)H-Index: 24
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Abstract Prenylated flavonoids are a unique class of naturally occurring flavonoids that have various pharmacological activities. In the present study, we investigated the anti-inflammatory effect in murine macrophages of a prenylated flavonoid, 10-oxomornigrol F (OMF), which was isolated from the twigs of Morus alba (Moraceae). OMF inhibited the lipopolysaccharide (LPS)-induced production of nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 in RAW264.7 cells, as ...
#2Van Thu Nguyen(DCU: Catholic University of Daegu)H-Index: 8
Last. Byung Sun Min(DCU: Catholic University of Daegu)H-Index: 53
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Abstract Five new compounds, 10-oxomornigrol F (1), (7″R)-(−)-6-(7″-hydroxy-3″,8″-dimethyl-2″,8″-octadien-1″-yl)apigenin (2), ramumorin A (3), ramumorin B (4), and (4S,7S,8R)-trihydroxyoctadeca-5Z-enoic acid (5), together with 31 known compounds (6–36), were isolated from the twigs of Morus alba (Moraceae). The chemical structures of these compounds were established using spectroscopic analyses, 1D and 2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and Mosher's meth...
#1Bai Lu(Northwest University (United States))H-Index: 6
#2Hai Zhang(Fourth Military Medical University)H-Index: 3
Last. Naisheng Bai(Northwest University (United States))H-Index: 13
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The fruit of Ziziphus jujuba Mill., also called hongzao in Chinese, has a long history of cultivation in China. From the fruit of Z. jujuba, twenty-seven known compounds were isolated and identified as the main constituents of these fruits. They were 3-O-(trans-p-coumaroyl)-alphitolic acid (1), 3-O-(cis-p-coumaroyl)-alphitolic acid (2), 3β-O-(trans-p-coumaroyl)-maslinic acid (3), pomonic acid (4), 2-oxo-pomolic acid (5), benthamic acid (6), terminic acid (7), oleanic acid (8), betulinic acid (9)...
#1Bini Wang(Northwest University (United States))H-Index: 14
#2Qingyuan Huang(Northwest University (United States))H-Index: 2
Last. Zhongli Pan(UC Davis: University of California, Davis)H-Index: 53
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Abstract This study investigated the changes in total phenolic content (TPC), total flavonoid content (TFC), individual phenolic compound content, DPPH radical scavenging activity and antioxidant capacity measured by FRAP assay of four phenolic fractions (free, esterified, glycosided and insoluble-bound) from jujube during three edible maturity stages. The maturity stages of jujubes were established as white maturity (WM), half-red maturity (HM) and red maturity (RM). The free fraction in jujube...
#1Chun-Lei Zhang(CPU: China Pharmaceutical University)H-Index: 13
#2Yan Wang(Peking Union Medical College)H-Index: 28
Last. De-Quan Yu(Peking Union Medical College)H-Index: 20
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Abstract Chemical examination of the ethanol extract of rhizomes of Iris tectorum led to the isolation and characterization of three new lignans, (7R,7′R,8S,8′S)-5′-methoxy-neo-olivil (1a), (7S,7′S,8R,8′R) -5′-methoxy-neo-olivil (1b), (7S,7′R,8S,8′S)-neo-olivil (2a), (7R,7′S,8R,8′R)-neo-olivil (2b), (7R,7′R,8S,8′S,7′′S,8′′S)-threo-neo-olivil-4′-O-8-guaiacylglycerol ether (3), together with six known ones (4–9). Among them, compounds 1 and 2 were found to be racemic mixtures, respectively, which ...
#1Pin-Yi Gao(SUCT: Shenyang University of Chemical Technology)H-Index: 13
#2Meng Wang(SUCT: Shenyang University of Chemical Technology)H-Index: 1
Last. Shao-Jiang Song(SPU: Shenyang Pharmaceutical University)H-Index: 21
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A lupane-type triterpene (1) featuring a rare 2-hemiacetal moiety in its A ring and aromatic ester derivatives (2–6) were isolated from the fruits of R. laevigata and evaluated to possess acetylcholinesterase and Aβ-aggregation inhibitory activities. Their structures were determined by multi-spectroscopic methods, chemosynthesis and CD analysis.
Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3-2-carbamothioyl...
Last. Huiyuan Gao(SPU: Shenyang Pharmaceutical University)H-Index: 12
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Abstract Our present and previous phytochemical investigations on Leptopus lolonum have resulted in the isolation of almost 30 phenylpropanoid-conjugated pentacyclic triterpenoids (PCPTs). During the continuous study on PCPTs, this kind of triterpenoid ester is considered as a natural product with low toxicity because of it’s widely distribution in natural plants and edible fruits including kiwi fruit, durian, jujube, pawpaw, apple and pear. In the present work, we report the isolation, structur...
Last. Xin Di(SPU: Shenyang Pharmaceutical University)
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Three undescribed sesquineolignans, Ziziphusmps A-C (1–3) were isolated from the seeds of Ziziphus jujuba. their gross structure was identified by comprehensive spectroscopic analyses. The part rel...
Last. Yong Nan Xu(SPU: Shenyang Pharmaceutical University)H-Index: 2
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Abstract Phytochemical investigations on the fruit stalks and seeds of the plant Hovenia dulcis Thunb. led to the isolation of twenty-one compounds, including three triterpenes (1–3), two sterols (4–5), five flavonoids (6–10), two sesquiterpenes (11–12), one lignan (13), two phenylpropanoids (14–15), four benzoic acid derivatives (16–19), one acid amide (20) and one cerebroside (21). The structures of these compounds were elucidated on the basis of spectroscopic analysis and comparison with prev...
Last. Hong-Xiang Lou(SDU: Shandong University)H-Index: 48
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Abstract Phytochemical investigation of the roots of Pueraria lobata led to the isolation of two pairs of new isoflavone glucosides, 3′-hydroxyneopuerarin A/B (1–2) and 3′-methoxyneopuerarin A/B (3–4). A pair of known compounds (5–6), which possess a very similar structure, were obtained together. Their structures were elucidated on the basis of spectroscopic data interpretation. Compounds 3–6 dose-dependently blocked the production of TNF-α and IL-6 in LPS-stimulated RAW264.7 cells, which indic...
Sixteen known compounds, including three lignan glycosides (1–3), seven phenolic glycosides (4–10), three glycosides (11–13), and three flavonoids (14–16), were isolated from the rhizomes of Actinidia kolomikta (Rupr. & Maxim.) Maxim., Actinidiaceae. Their structures were elucidated through extensive spectroscopic analyses and comparison with those reported in the literature. This study is the first confirmation of the presence of the twelve compounds (1–4, 6–13) isolated from the Actinidiaceae ...