Anti-inflammatory and cytotoxic activities of constituents isolated from the fruits of Ziziphus jujuba var. inermis Rehder.

Published on Sep 1, 2019in Fitoterapia2.527
· DOI :10.1016/J.FITOTE.2019.104261
Huynh Nguyen Khanh Tran2
Estimated H-index: 2
(CUA: The Catholic University of America),
Thao Quyen Cao4
Estimated H-index: 4
(CUA: The Catholic University of America)
+ 2 AuthorsByung Sun Min23
Estimated H-index: 23
(CUA: The Catholic University of America)
Abstract Three new sesquilignans, zijusesquilignans A-C ( 1 – 3 ), together with fifteen known compounds ( 4 – 18 ), were isolated from fruits of Ziziphus jujuba var. inermis Rehder (Rhamnaceae) . Their chemical structures were established using spectroscopic analyses including 1D- and 2D-NMR, HR-EIMS, and ECD spectra. These compounds were assessed for their inhibitory effects on nitric oxide (NO) production. Of these compounds, 1 – 3 and 17 displayed inhibitory effects on NO production, with IC 50 values ranging from 18.1 to 66.4 μM. Pretreatment with 1 and 17 significantly suppressed LPS-induced expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein in cells. Moreover, compounds 1 – 3 , 7 , 9 , and 17 exhibited cytotoxic activities against three human tumor cell lines, with IC 50 values ranging from 8.4 to 44.9 μM.
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