Tunable Hydrophile–Lipophile Balance for Manipulating Structural Stability and Tumor Retention of Amphiphilic Nanoparticles

Hydrophile–lipophile balance (HLB) has a great influence on the self‐assembly and physicochemical properties of amphiphiles, thus affecting their biological effects. It is shown that amphiphilic nanoparticles (NPs) with a moderate HLB value display enhanced stability and highly efficient tumor retention. 2,2‐Bis(hydroxymethyl)propionic acid hyperbranched poly(ethylene glycol) (PEG)–pyropheophorbide‐a (Ppa) amphiphiles (G320P, G310P, G220P, and...