Gene

Genetic enhancement

Nanoparticle

Biotechnology

Biology

Biomedical engineering

Materials science

Gene delivery

Adjuvant

Cancer research

Biochemistry

Drug

Immunology

Drug delivery

In vivo

Cancer immunotherapy

Nanotechnology

Immune system

Photothermal therapy

Internal medicine

Pharmacology

Nanoshell

Oncology

Medicine

Chemistry

Immunotherapy

Cancer

Journal of Nanobiotechnology

The gastric cancer is the second most malignant tumor in the world. HER-2 is one of the key targets for the gastric cancer therapy. Anti-HER-2 antibodies like trastuzumab, exhibits the satisfactory therapeutic effect in clinical. However, the drug resistance problem limits its application.In this study, we develop a gold nanoshell (Gold Nanoshell) drug carrier for delivery and selective photo-thermal release of genes which target HER-2 and immunologic adjuvant CPG sequence in gastric tumor cells. The drug delivery system generated a multidimensional treatment strategy which includes gene-, immune- and photothermal-therapy.The whole gold nanoshell drug delivery system exhibits the well gene transduction ability and combined treatment effect. Both in vitro and in vivo results demonstrate the multiple therapeutic effects of the drug delivery system is better than the monotherapy.This study indicates the multiple combined therapy based on the gold nanoshell system would be a promising translational treatment for gastric cancer.

Photothermal and gene therapy combined with immunotherapy to gastric cancer by the gold nanoshell-based system