doi.org/10.1111/bcpt.13279
Original paper

Metformin inhibits Aβ25‐35‐induced apoptotic cell death in SH‐SY5Y cells

..., Yan-Qiang Liu
12
Basic & Clinical Pharmacology & Toxicology2.70
Volume: 125, Issue: 5, Pages: 439 - 449
Published: Jul 9, 2019
Abstract
Metformin, a first-line drug for type-2 diabetes, plays a potentially protective role in preventing Alzheimer's disease (AD), but its underlying mechanism is unclear. In this study, Aβ25-35 -treated SH-SY5Y cells were used as a cell model of AD to investigate the neuroprotective effect of metformin, as well as its underlying mechanisms. We found that metformin decreased the cell apoptosis rate and death, ratio of Bcl-2/Bax, and expression of...
Paper Fields
Paper Details
Title
Metformin inhibits Aβ25‐35‐induced apoptotic cell death in SH‐SY5Y cells
DOI
doi.org/10.1111/bcpt.13279
Published Date
Jul 9, 2019
Journal
Basic & Clinical Pharmacology & Toxicology
Volume
125
Issue
5
Pages
439 - 449
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