Basic & Clinical Pharmacology & Toxicology
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#1Krzysztof Łukawski (Medical University of Lublin)H-Index: 10
#2Stanisław J. Czuczwar (Medical University of Lublin)H-Index: 60
Hypertension is a common comorbid condition with epilepsy, and drug interactions between antihypertensive and antiepileptic drugs (AEDs) are likely in patients. Experimental studies showed that centrally active imidazoline compounds belonging to antihypertensive drugs can affect seizure susceptibility. The purpose of this study was to assess the effect of moxonidine, an I1 -imidazoline receptor agonist, on the anticonvulsant efficacy of numerous AEDs (carbamazepine, phenobarbital, valproate, phe...
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#1Almut G. Winterstein (UF: University of Florida)H-Index: 28
#2Patrick J. Antonelli (UF: University of Florida)H-Index: 29
Background null The scientific method requires studies with high internal and external validity. Though both are necessary, they do not go hand-in-hand: The more controlled a study is to enhance internal validity, the less applicable to real-world clinical care, and vice versa. In the many instances where evidence from clinical trials is not available, scientific inference must rely on more extreme approaches on this spectrum, such as mechanistic (limited generalizability/strong bias control) an...
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#1Rodrigo Bitencourt da Rosa (ULBRA: Universidade Luterana do Brasil)
#2Guilherme Borsoi (ULBRA: Universidade Luterana do Brasil)
Last. Alexandre de Barros Falcão Ferraz (ULBRA: Universidade Luterana do Brasil)H-Index: 18
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Plants of the Calea genus have been reported to contain lipophilic compounds, such as sesquiterpene lactones, with cytotoxic effect against different cancer cell lines. The aim of this manuscript was to investigate the chemical profile and cytotoxic activity of different fractions from Calea phylolepis leaves on different human cancer cell lines. The fractions were prepared using solvent extraction of increasing polarity, yielding hexane, ethyl acetate and methanolic fractions. All fractions wer...
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#1Ida Kuhlmann (University of Southern Denmark)H-Index: 1
Last. Anders Gadegaard Jensen (OUH: Odense University Hospital)H-Index: 3
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We investigated the impact of genetic variants in OCT1 (SLC22A1) on morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) pharmacokinetics in adult patients scheduled for major surgery. Blood samples were taken before and 5, 10, 15, 30, 45, 60 and 90 min after a bolus of morphine (0.15 mg/kg). Patients were genotyped for the genetic variants (rs12208357, rs34059508, rs72552763 and rs34130495) in OCT1. Eighty-six patients completed the trial. The mean difference (95% confidence ...
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#1Gudrun Høiseth (University of Oslo)H-Index: 19
#2Thor HilbergH-Index: 9
Last. Stig Tore Bogstrand (University of Oslo)H-Index: 10
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BACKGROUND The aim of this study was to evaluate the quantitative relation between common clinical chemical analyses and ethanol use, measured by a combination of the two alcohol markers phosphatidylethanol (PEth) and carbohydrate-deficient transferrin (CDT). METHODS Results of PEth and CDT in whole blood and serum, respectively, were included, together with information on 10 different commonly measured clinical chemical analytes, as well as age and sex. PEth was analysed by UPC2 -MS/MS and CDT ...
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#1Elin Ngo (University of Oslo)H-Index: 1
#2Olav Spigset (NTNU: Norwegian University of Science and Technology)H-Index: 53
Last. Hedvig Nordeng (University of Oslo)H-Index: 41
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Current data on use of antihistamines during breastfeeding and risks to the breastfed infant are insufficient. The aim of this systematic review was to provide an overview of studies measuring the levels of antihistamines in human breast milk, estimating the exposure for breastfed infants, and/or reporting possible adverse effects on the breastfed infant. An additional aim was to review the antihistamine product labels available in EU and the US. We searched seven online databases and identified...
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#1Bensu Karahalil (Gazi University)H-Index: 28
#2E. Miser Salihoğlu (Gazi University)
Last. S. Akaydin Yardim (Gazi University)
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Oxidative stress plays an important role in the degeneration of dopaminergic neurons which causes Parkinson's disease (PD). Oxidative stress products, antioxidant and their balance have important roles in the development of oxidative stress-based PD. The impact of Reactive Oxygen Species (ROS) and defence systems can be altered by genetic polymorphisms, and thus the risk of PD may also be affected. We aimed to investigate the possible association of individual susceptibility with the development...
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#1Xing Dai (WHU: Wuhan University)
#2Tiechi Lei (WHU: Wuhan University)
Keloid is a type of unusually raised scar. Botulinum toxin A (BTX-A) has a great application potential in keloids treatment. Here, we investigated the functional role of BTX-A in keloids. We separated keloid tissues and normal skin tissues from keloid patients and found that the expression of myofibroblast markers, α-SMA, Collagen I, and Collagen III was increased in the keloid tissues as compared with normal skin tissues. Keloid fibroblasts derived from keloid tissues were treated with TGF-β1 t...
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#1Jørgen G. Bramness (FHI: Norwegian Institute of Public Health)H-Index: 29
#2Vidar Hjellvik (FHI: Norwegian Institute of Public Health)H-Index: 14
Last. Svetlana Skurtveit (University of Oslo)H-Index: 40
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Some ecological studies have shown that areas with higher use of cannabis may have lower opioid use and fewer opioid-related problems. Newer studies are questioning this finding. Few individually based studies have been performed. Using data from the Norwegian Prescription Database, this study investigated the individual level effect of prescribed cannabis extract (Sativex®) in prescription opioid users on their opioid use in the following year. Looking at all those filling a prescription for Sa...
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