Segmentation of Glomeruli Within Trichrome Images Using Deep Learning

The number of glomeruli and glomerulosclerosis evaluated on kidney biopsy slides constitute standard components of a renal pathology report. Prevailing methods for glomerular assessment remain manual, labor intensive, and nonstandardized. We developed a deep learning framework to accurately identify and segment glomeruli from digitized images of human kidney biopsies.Trichrome-stained images (n = 275) from renal biopsies of 171 patients with...