Histone

Gene

Neuroscience

Prefrontal cortex

Biology

Epigenetics

Dorsolateral prefrontal cortex

Cognition

Alzheimer's disease

DNA methylation

Computational biology

Biomarker

Genetics

Bioinformatics

Cognitive decline

Internal medicine

Dementia

Medicine

Disease

Gene expression

Scientific Data

We initiated the systematic profiling of the dorsolateral prefrontal cortex obtained from a subset of autopsied individuals enrolled in the Religious Orders Study (ROS) or the Rush Memory and Aging Project (MAP), which are jointly designed prospective studies of aging and dementia with detailed, longitudinal cognitive phenotyping during life and a quantitative, structured neuropathologic examination after death. They include over 3,322 subjects. Here, we outline the first generation of data including genome-wide genotypes ( n =2,090), whole genome sequencing ( n =1,179), DNA methylation ( n =740), chromatin immunoprecipitation with sequencing using an anti-Histone 3 Lysine 9 acetylation (H3K9Ac) antibody ( n =712), RNA sequencing ( n =638), and miRNA profile ( n =702). Generation of other omic data including ATACseq, proteomic and metabolomics profiles is ongoing. Thanks to its prospective design and recruitment of older, non-demented individuals, these data can be repurposed to investigate a large number of syndromic and quantitative neuroscience phenotypes. The many subjects that are cognitively non-impaired at death also offer insights into the biology of the human brain in older non-impaired individuals.

A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research