A Non-infringing Route for Enantioselective Synthesis of Antiepileptic Agent Lacosamide
Abstract
A non-infringing route for enantioselective synthesis of lacosamide has been developed. The synthesis started from commercially available acrylic acid and was completed in eight steps using Sharpless asymmetric dihydroxylation as a key step with an overall yield of 29%. All the reactions were very clean with good...
Paper Details
Title
A Non-infringing Route for Enantioselective Synthesis of Antiepileptic Agent Lacosamide
Published Date
Oct 2, 2013
Journal
Volume
45
Issue
24
Pages
3383 - 3386
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Notes
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