Review paper
CD95/Fas and metastatic disease: What does not kill you makes you stronger
Abstract
CD95 (also known as Fas) is the prototype of death receptors; however, evidence suggests that this receptor mainly implements non-apoptotic signaling pathways such as NF-κB, MAPK, and PI3K that are involved in cell migration, differentiation, survival, and cytokine secretion. At least two different forms of CD95 L exist. The multi-aggregated transmembrane ligand (m-CD95 L) is cleaved by metalloproteases to release a homotrimeric soluble ligand...
Paper Details
Title
CD95/Fas and metastatic disease: What does not kill you makes you stronger
Published Date
Feb 1, 2020
Journal
Volume
60
Pages
121 - 131
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