Patrick Legembre
French Institute of Health and Medical Research
Cell migrationMolecular biologyCytotoxic T cellReceptorJurkat cellsTumor necrosis factor alphaChemistryApoptosisImmunologyFADDInflammationTriple-negative breast cancerFas receptorCancer researchSignal transductionFas ligandMedicineLipid raftPI3K/AKT/mTOR pathwayBiologyImmune systemCell biologyCancer cell
82Publications
28H-index
5,214Citations
Publications 82
Newest
#1Ludivine Dion (French Institute of Health and Medical Research)H-Index: 4
#2Maela Le LousH-Index: 6
Last. Vincent Lavoué (French Institute of Health and Medical Research)H-Index: 22
view all 13 authors...
Abstract Background Uterine transplant (UT) represents an opportunity to treat absolute uterine infertility. However, the use of uterine veins for venous return, in addition to ovarian veins, significantly increases the risk of ureteral wounds in the living donor and UT time for the recipient. Our aim was to demonstrate that dual ovarian venous return is sufficient for graft viability and survival. Methods Uterine orthotopic auto-transplant was performed under general anaesthesia in six Yucatan ...
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#1Keerthi Kurma (University of Limoges)
#2Andrea Boizard-Moracchini (University of Bordeaux)H-Index: 1
Last. Patrick Legembre (University of Limoges)H-Index: 28
view all 7 authors...
Abstract null null Although CD95L (also known as FasL) is still predominantly considered as a death ligand that induces apoptosis in infected and transformed cells, substantial evidence indicate that it can also trigger non-apoptotic signaling pathways whose pathophysiological roles remain to be fully elucidated. The transmembrane ligand CD95L belongs to the tumor necrosis factor (TNF) superfamily. After cleavage by metalloprotease, its soluble form (s-CD95L) fails to trigger the apoptotic progr...
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#1Marc Scherlinger (University of Bordeaux)H-Index: 10
#2Vivien Guillotin (University of Bordeaux)H-Index: 3
Last. Emmanuel RibeiroH-Index: 1
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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by a loss of tolerance toward self-nucleic acids, autoantibody production, interferon expression and signaling, and a defect in the regulatory T (Treg) cell compartment. In this work, we identified that platelets from patients with active SLE preferentially interacted with Treg cells via the P-selectin/P-selectin glycoprotein ligand-1 (PSGL-1) axis. Selectin interaction with PSGL-1 blocked the regulatory and suppre...
1 CitationsSource
#1J. P. Guegan (French Institute of Health and Medical Research)H-Index: 1
Last. Patrick LegembreH-Index: 28
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CD95L is expressed by tumor-infiltrating lymphocytes to eliminate CD95-expressing tumor cells and thereby CD95 loss by tumor cells is often considered as a consequence of an immunoediting process. Nonetheless CD95 expression is maintained in most triple negative breast cancers (TNBCs), and we recently reported that CD95 loss in TNBC cells triggers the induction of a pro-inflammatory program promoting the recruitment of cytotoxic NK and CD8+ T-cells and impairing tumor growth. Using a comprehensi...
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The apoptosis inducing receptor CD95/Fas has multiple tumorigenic activities. Stimulation by its cognate ligand CD95L on many cancer cells increases their growth, motility, ability to invade and/or their cancer stemness. Using genetically engineered mouse models of ovarian and liver cancer, we previously reported that deletion of CD95 in the tumor cells strongly reduced their ability to grow in vivo [1, 2]. Using a combination of immune-deficient and immune-competent mouse models, we now establi...
2 CitationsSource
#1Eva Szegezdi (NUI: National University of Ireland)H-Index: 30
#2Patrick Legembre (French Institute of Health and Medical Research)H-Index: 28
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#1Nicolas LevoinH-Index: 9
#2Mickael Jean (University of Rennes)H-Index: 9
Last. Patrick Legembre (University of Limoges)H-Index: 28
view all 3 authors...
: CD95 is a pre-ligand-associated transmembrane (TM) receptor. The interaction with its ligand CD95L brings to a next level its aggregation and triggers different signaling pathways, leading to cell motility, differentiation or cell death. This diversity of biological responses associated with a unique receptor devoid of enzymatic property raises the question of whether different ligands exist, or whether the fine-tuned control of CD95 aggregation and conformation, its distribution within certai...
6 CitationsSource
#1Jean Philippe Guégan (French Institute of Health and Medical Research)H-Index: 1
#2Christophe Ginestier (AMU: Aix-Marseille University)H-Index: 48
Last. Patrick Legembre (French Institute of Health and Medical Research)H-Index: 28
view all 7 authors...
Abstract CD95 (also known as Fas) is the prototype of death receptors; however, evidence suggests that this receptor mainly implements non-apoptotic signaling pathways such as NF-κB, MAPK, and PI3K that are involved in cell migration, differentiation, survival, and cytokine secretion. At least two different forms of CD95 L exist. The multi-aggregated transmembrane ligand (m-CD95 L) is cleaved by metalloproteases to release a homotrimeric soluble ligand (s-CD95 L). Unlike m-CD95 L, the interactio...
6 CitationsSource
#1Marie BénéteauH-Index: 11
#2Sophie DaburonH-Index: 16
Last. Patrick LegembreH-Index: 28
view all 5 authors...
The editors are publishing this note to alert readers to concerns about [this article][1] ([1][2]). The same Western blot analysis image was used for Jurkat-R cells in Fig. 4A and for Jurkat parental cells in Fig. 1B of another article previously published by the authors ([2][3]). In addition, lane
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#1Thibault De La Motte Rouge (French Institute of Health and Medical Research)H-Index: 17
#2Julien Corné (French Institute of Health and Medical Research)H-Index: 1
Last. Vincent Lavoué (French Institute of Health and Medical Research)H-Index: 22
view all 15 authors...
Soluble CD95L (s-CD95L) is a chemoattractant for certain lymphocyte subpopulations. We examined whether this ligand is a prognostic marker for high grade serous ovarian cancer (HGSOC) and whether it is associated with accumulation of immune cells in the tumor. Serum s-CD95L levels in 51 patients with advanced ovarian cancer were tested by ELISA. Immunohistochemical staining of CD3, CD4, CD8, CD20, CD163, CD31, FoxP3, CCR6, IL-17, Granzyme B, PD-L1, and membrane CD95L was used to assess tumor-inf...
5 CitationsSource