Original paper
Super-Mendelian inheritance mediated by CRISPR–Cas9 in the female mouse germline
Abstract
A gene drive biases the transmission of one of the two copies of a gene such that it is inherited more frequently than by random segregation. Highly efficient gene drive systems have recently been developed in insects, which leverage the sequence-targeted DNA cleavage activity of CRISPR–Cas9 and endogenous homology-directed repair mechanisms to convert heterozygous genotypes to homozygosity1–4. If implemented in laboratory rodents, similar...
Paper Details
Title
Super-Mendelian inheritance mediated by CRISPR–Cas9 in the female mouse germline
Published Date
Jan 23, 2019
Journal
Volume
566
Issue
7742
Pages
105 - 109