Biotechnology

Biology

Statistics

Systematic error

Biochemistry

Food science

Regression analysis

Systematic review

Ochratoxin

Veterinary medicine

Meta-regression

Mathematics

Toxicology

Meta-analysis

Internal medicine

Ochratoxin A

MEDLINE

Green coffee

Medicine

Mycotoxin

Fungal Biology

The current investigation was aimed to estimate the prevalence and concentration of ochratoxin A (OTA) in different types of coffee and coffee-based products with the aid of a systematic review and meta-analysis. Therefore, the recommended databases including PubMed, Scopus, and Embase from Jan 1983 to Oct 2018 were screened to retrieve the related citations. In this regard, among 1041 explored articles in the identification step, thirty six articles with 3182 samples were included in the meta-analysis and meta-regression. According to findings, the global pooled concentration and prevalence of OTA was calculated as 3.21 μg/kg (95% CI: 3.08-3.34 μg/kg) and 53.0 % (95% CI: 43.0-62.0), respectively. Also, direct correlations between the increases in poverty as well as the amount of annual precipitation and prevalence of OTA was noted, while with decreasing in HDI the prevalence of OTA in coffee significantly was increased. Moreover, the lowest and highest concentrations of OTA in coffee were observed in Taiwan (0.35 μg/kg) and Turkey (79.0 μg/kg), respectively. The outcome of this meta-analysis can be used for the building of risk assessment models aiming to derive data for the development of specific actions to reduce the exposure to this mycotoxin in coffee and coffee-based products.

The concentration and prevalence of ochratoxin A in coffee and coffee-based products: A global systematic review, meta-analysis and meta-regression