Original paper
Tyrosine kinase inhibitors relax pulmonary arteries in human and murine precision-cut lung slices
Abstract
Tyrosine kinase inhibitors (TKIs) inhibit the platelet derived growth factor receptor (PDGFR) and gain increasing significance in the therapy of proliferative diseases, e.g. pulmonary arterial hypertension (PAH). Moreover, TKIs relax pulmonary vessels of rats and guinea pigs. So far, it is unknown, whether TKIs exert relaxation in human and murine pulmonary vessels. Thus, we studied the effects of TKIs and the PDGFR-agonist PDGF-BB in...
Paper Details
Title
Tyrosine kinase inhibitors relax pulmonary arteries in human and murine precision-cut lung slices
Published Date
Jun 6, 2019
Journal
Volume
20
Issue
1