Respiratory Research
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#1Anna Lindahl (UH: University of Helsinki)
#2Jere Reijula (UH: University of Helsinki)H-Index: 2
Last. Mika J. Mäkelä (UH: University of Helsinki)H-Index: 61
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Follow-up studies of COVID-19 patients have found lung function impairment up to six months after initial infection, but small airway function has not previously been studied. Patients (n = 20) hospitalised for a severe SARS-CoV-2 infection underwent spirometry, impulse oscillometry, and multiple measurements of alveolar nitric oxide three to six months after acute infection. None of the patients had small airway obstruction, nor increased nitric oxide concentration in the alveolar level. None o...
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#1Huiyuan Wang (Xi'an Jiaotong University)
#2Bo Zhong (Xi'an Jiaotong University)
Last. Wei Hou (Xi'an Jiaotong University)
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BACKGROUND Childhood asthma is a common respiratory disease characterized by airway inflammation. Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) has been found to be involved in the progression of asthma. This study aimed to explore the role of TIPE2 in the regulation of airway smooth muscle cells (ASMCs), which are one of the main effector cells in the development of asthma. MATERIALS AND METHODS ASMCs were transfected with pcDNA3.0-TIPE2 or si-TIPE2 for 48 h and then treated with pla...
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#1Hyung Jun Kim (Seoul National University Bundang Hospital)H-Index: 2
#2Kyeongman Jeon (SMC: Samsung Medical Center)H-Index: 39
Last. Jae Hwa Cho (Yonsei University)H-Index: 17
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BACKGROUND Rapid response systems (RRSs) improve patients' safety, but the role of dedicated doctors within these systems remains controversial. We aimed to evaluate patient survival rates and differences in types of interventions performed depending on the presence of dedicated doctors in the RRS. METHODS Patients managed by the RRSs of 9 centers in South Korea from January 1, 2016, through December 31, 2017, were included retrospectively. We used propensity score-matched analysis to balance pa...
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#1Spela Kokelj (University of Gothenburg)H-Index: 1
#2Jörgen Östling (AstraZeneca)H-Index: 16
Last. Anna-Carin Olin (University of Gothenburg)H-Index: 23
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INTRODUCTION Cigarette smoke triggers many cellular and signaling responses in the lung and the resulting inflammation plays a central role in smoke-related lung diseases, such as COPD. We explored the effects of smoking on the small airway proteome in samples obtained by collection of exhaled particles with the aim to identify specific proteins dysregulated by smoking. METHODS Exhaled particles were obtained from 38 current smokers, 47 former smokers and 22 healthy controls with the PExA method...
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#1Ayumi Mitsune (Tohoku University)H-Index: 2
#2Mitsuhiro Yamada (Tohoku University)H-Index: 28
Last. Tomonori Makiguchi (Tohoku University)H-Index: 5
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BACKGROUND Leukocyte immunoglobulin-like receptor B4 (LILRB4) is one of the inhibitory receptors in various types of immune cells including macrophages. Previous reports suggested that LILRB4 could be involved in a negative feedback system to prevent excessive inflammatory responses. However, its role has been unclear in chronic obstructive pulmonary disease (COPD), in which macrophages play a crucial role in the pathogenesis. In this study, we aimed to examine the changes of LILRB4 on macrophag...
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#1Jie Li (Rush University Medical Center)H-Index: 13
#2Ashley E. Augustynovich (Rush University Medical Center)H-Index: 1
Last. James B Fink (Rush University)
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BACKGROUND Inhaled epoprostenol (iEPO) has been shown to reduce pulmonary artery pressure and improve oxygenation. iEPO is mainly delivered via a syringe pump with feed tubing connected to a vibrating mesh nebulizer with high or low formulation concentration delivery. METHODS An in vitro study and a two-period retrospective case-control study were implemented. The in vitro study compared iEPO delivery via invasive ventilation at low concentrations of 7.5, and 15 mcg/mL and high concentration at ...
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#1Ivan Ramirez‐Moral (UvA: University of Amsterdam)H-Index: 1
#2Bianca Lima Ferreira (UNIFESP: Federal University of São Paulo)
Last. Tom van der Poll (UvA: University of Amsterdam)H-Index: 116
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Agonists of peroxisome proliferator-activated receptor (PPAR)-γ have been suggested as potential adjuvant therapy in bacterial pneumonia because of their capacity to inhibit inflammation and enhance bacterial clearance. Previous studies only assessed the effects of pretreatment with these compounds, thereby bearing less relevance for the clinical scenario. Moreover, PPAR-γ agonists have not been studied in pneumonia caused by Klebsiella pneumoniae, a common human respiratory pathogen of which an...
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#1Anouk Delameillieure (Katholieke Universiteit Leuven)
#2Sarah Vandekerkhof (Katholieke Universiteit Leuven)
Last. Fabienne Dobbels (Katholieke Universiteit Leuven)H-Index: 56
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Background null The multidimensional and complex care needs of patients with idiopathic pulmonary fibrosis (IPF) call for appropriate care models. This systematic review aimed to identify care models or components thereof that have been developed for patients with IPF in the outpatient clinical care, to describe their characteristics from the perspective of chronic integrated care and to describe their outcomes. null Methods null A systematic review was conducted using state-of-the-art methodolo...
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#1Manuel B. HuberH-Index: 7
#2Nelli Schneider (LMU: Ludwig Maximilian University of Munich)
Last. Reiner Leidl (LMU: Ludwig Maximilian University of Munich)H-Index: 37
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BACKGROUND Little is known about how long-term weight gain affects the health perception of COPD patients. OBJECTIVES The aim is to evaluate the long-term association of BMI change and health-related quality of life (HRQoL) in obese COPD patients. METHODS Claims and survey data from a COPD disease management program were used to match two groups of COPD patients with BMI ≥ 30 who have differing weight trajectories over a 5-year timespan via propensity score and genetic matching. EQ-5D-5L, includ...
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#1Severin Vogt (University Hospital of Basel)
#2Jörg D. LeuppiH-Index: 30
Last. Michael Osthoff (University Hospital of Basel)H-Index: 14
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Background null The innate and adaptive immune system is involved in the airway inflammation associated with acute exacerbations in patients with chronic obstructive pulmonary disease (COPD). We evaluated the association of mannose-binding lectin (MBL), immunoglobulin (Ig) and ficolin-2 concentrations with COPD exacerbations and according to the glucocorticoid treatment duration for an index exacerbation. null Methods null Post-hoc analysis of the randomized, double-blind, placebo-controlled RED...
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Top fields of study
Immunology
COPD
Lung
Diabetes mellitus
Medicine
Biology