Pharmacokinetic and tissue distribution studies of cassane diterpenoids, in rats through an ultra‐high‐performance liquid chromatography–Q exactive hybrid quadrupole–Orbitrap high‐resolution accurate mass spectrometry

Cassane diterpenoids (CA) are considered as the main active constituents of medicinal plants belonging to the Caesalpinia genus. Three cassane derivatives, bonducellpin G (BG), 7‐ O ‐acetyl‐bonducellpin C (7‐ O ‐AC) and caesalmin E (CE), isolated from Caesalpinia minax Hance seeds, showed strong anti‐inflammatory activity. In this paper, pharmacokinetics (BG, 7‐ O ‐AC, CE) and tissue distribution (7‐ O ‐AC, CE) properties were studied for the...