Biomedical Chromatography
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#1Yan Li (PKU: Peking University)H-Index: 3
#2Ying-Yuan Lu (PKU: Peking University)H-Index: 4
Last. Xiao-Yu Guo (PKU: Peking University)H-Index: 11
view all 9 authors...
Notoginseng total saponins (NS), safflower total flavonoids (SF) and the combination of NS and SF, namely CNS are used for the treatment of cardiovascular disease (CD) in clinic. In the study, a cocktail assay involving seven cytochrome P450 (CYP) enzymes was performed to elucidate the effect of NS, SF and CNS on CYP enzymes and to explore the synergistic effect of CNS in terms of CYP enzymes. UPLC/MS and RT-PCR were applied to detect the activities and mRNA expression levels of CYP enzymes. SF ...
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#1Qian-Qian Pang (JNU: Jinan University)H-Index: 2
#2Ting Li (JNU: Jinan University)H-Index: 2
Last. Yang Yu (JNU: Jinan University)H-Index: 13
view all 7 authors...
Cimicifuga dahurica (Turcz.) Maxim, which is also regarded as the main origin of "shengma" in Chinese Pharmacopoeia, has been used as cooling and detoxification agents for thousands of years. Our previous phytochemical investigations of C. dahurica extracts (CDEs) led to the isolation of a series of 9, 19-cycloalkane triterpenoids and phenolic acids showing a potential anti-inflammatory activity. However, the chemical profiling of CDEs and the material basis of its anti-inflammatory effect in vi...
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#1Namburi La Amara babu (Vignan University)H-Index: 1
#2Kalyani Koganti (Vignan University)H-Index: 1
Last. Koya Prabhakara Rao (Vignan University)H-Index: 1
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A new RP-HPLC method with a quick, sensitive and stable indication for the quantitative measurement of Selexipag and their associated substances were developed and validated in the present study. In this new method, using the impurity-spiked solution, the chromatographic approach was optimized. Similarly, using the X-bridge phenyl column with isocratic elution of mobile phase containing acetonitrile and formic acid, the separation of Selexipag and its impurities were achieved. Recovery experimen...
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#1Lu YuanH-Index: 1
Last. Liu Chunhua (MOE: Chinese Ministry of Education)H-Index: 2
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Polygonum orientale L. is a traditional Chinese medicine having such extensive pharmacological activities as anti-myocardial ischemia (MI) injury properties. Isoorientin, orientin, vitexin, quercitrin, astragalin, and protocatechuic acid are the main compounds in P. orientale extract (POE). The aim of this study was to establish a ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of the content of these compounds in urine, feces, and bile ...
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#2Chunyu Wang (Chinese Academy of Fishery Sciences)
Last. Jincheng Li (Chinese Academy of Fishery Sciences)H-Index: 8
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A novelty single step clean-up method was developed for analysis of tricaine, tetracaine and bupivacaine in fish tissue combined with high performance liquid chromatography coupled with triple quadrupole-linear ion trap tandem mass spectrometry (HPLC-QTRAP-MS/MS). The target analytes were extracted by acetonitrile based on modified QuEChERS (quick, easy, cheap, effective, rugged and safe) method under ultrasound irradiation. A cheap analytical filtration syringe (CAFS) clean-up column for single...
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#1Sijie Zhang (ZJU: Zhejiang University)
#2Linlin Wu (ZJU: Zhejiang University)
Last. Haibin Qu (ZJU: Zhejiang University)H-Index: 28
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Previously reported HPLC-evaporative light scattering detection (ELSD) methods for terpene trilactone determination in Ginkgo biloba leaf extract (EGBL) with complicated sample preparation are time-consuming. Thus, in this work, an HPLC-MS method for the determination of terpene trilactones in EGBL was developed with a novel analytical quality by design (AQbD) approach to provide robust and simple measurements. For this purpose, analytical target profiles and systematic risk analyses were perfor...
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#1Yaxin Li (CSU: Cleveland State University)H-Index: 1
#2Cody M. Orahoske (CSU: Cleveland State University)H-Index: 1
Last. Bin Su (CSU: Cleveland State University)H-Index: 19
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Previously compound 12 showed great anti-trypanosome activity without toxicity in the in vivo study. In the current study, a sensitive and rapid high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed and validated to investigate the pharmacokinetics of compound 12 in mouse plasma. Protein precipitation method was applied to extract the compound, and it was then separated by using a Kinetex C18 column with a mobile phase consisting of acetonitrile-0.1% f...
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#1Yao Rui (Fourth Military Medical University)
#2Yu Cao (Fourth Military Medical University)
Last. Siwang Wang (Fourth Military Medical University)H-Index: 28
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Hydroxysafflor yellow A (HSYA), a major active water-soluble component in Carthamus tinctorius L., is considered a potential antioxidant with protective effects against myocardial injury. However, its pharmacokinetic characteristics in normal and diabetic cardiomyopathy (DCM) mice remain unknown. This study was designed to investigate the differences in the pharmacokinetics of HSYA between normal and streptozotocin-induced DCM mice. HSYA in the mouse plasma was quantified by liquid chromatograph...
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#1Cancan Duan (Zunyi Medical College)H-Index: 1
#2Weina Cheng (Zunyi Medical College)
Last. Jian-Yong Zhang (Zunyi Medical College)H-Index: 2
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A sensitive gas chromatography-mass spectroscopy (GC-MS/MS) method was established for the determination of cantharidin (CTD) in rat plasma and liver homogenates. During the experiment, rats were randomly divided into two groups (low, high) and were administered with aqueous extract of Mylabris compound (AEMC) for 7 days. Then, plasma and tissue samples were taken at different time points to study the pharmacokinetics and tissue distribution of CTD in rats. The selected reaction monitoring trans...
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Adenine nucleotides and malondialdehyde are key components involved in energy metabolism and reactive oxygen species production. Measuring the levels of these components at the same time would be critical in studying mitochondrial functions. We have established an HPLC method to simultaneously measure ATP, ADP, AMP, malondialdehyde and uric acid. Samples were treated with perchloric acid followed by centrifugation. After neutralization, the supernatant was subjected to HPLC determination. HPLC w...
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Top fields of study
Pharmacokinetics
Analytical chemistry
Detection limit
High-performance liquid chromatography
Chemistry
Chromatography