Pathology

Interstitial fluid

Lymphatic vessel

Biology

Cancer

Lymphatic system

Acquired immune system

Immunology

Inflammation

Metastasis

Lymph

Innate lymphoid cell

Lymphatic Endothelium

Genetics

Medicine

Immune system

Frontiers in Immunology

Lymphatic vessels collect interstitial fluid that has extravasated from blood vessels and return it to the circulatory system. Another important function of the lymphatic network is to facilitate immune cell migration and antigen transport from the periphery to draining lymph nodes. This migration plays a crucial role in immune surveillance, initiation of immune responses and tolerance. Here we discuss the significance and mechanisms of lymphatic migration of innate and adaptive immune cells in homeostasis, inflammation and cancer.

Lymphatic Migration of Immune Cells