TCF-1 limits the formation of Tc17 cells via repression of the MAF–RORγt axis

Volume: 216, Issue: 7, Pages: 1682 - 1699
Published: May 29, 2019
Abstract
Interleukin (IL)-17-producing CD8+ T (Tc17) cells have emerged as key players in host-microbiota interactions, infection, and cancer. The factors that drive their development, in contrast to interferon (IFN)-γ-producing effector CD8+ T cells, are not clear. Here we demonstrate that the transcription factor TCF-1 (Tcf7) regulates CD8+ T cell fate decisions in double-positive (DP) thymocytes through the sequential suppression of MAF and RORγt, in...
Paper Details
Title
TCF-1 limits the formation of Tc17 cells via repression of the MAF–RORγt axis
Published Date
May 29, 2019
Volume
216
Issue
7
Pages
1682 - 1699
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