Original paper

Imiquimod‐induced skin inflammation is relieved by knockdown of sodium channel Na x

Volume: 28, Issue: 5, Pages: 576 - 584
Published: May 1, 2019
Abstract
Nax is an atypical sodium channel that mediates inflammatory pathways in pathological conditions of the skin. In this study, we developed a skin inflammation model in the rabbit ear through application of imiquimod (IMQ). Knockdown of Nax using RNAi attenuated IMQ-induced skin inflammation, including skin erythema, scaling and papule formation. Histologic analysis showed that thickening and insufficient differentiation of the epidermis found in...
Paper Details
Title
Imiquimod‐induced skin inflammation is relieved by knockdown of sodium channel Na x
Published Date
May 1, 2019
Volume
28
Issue
5
Pages
576 - 584
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